Recent Developments in Knoevenagel Condensation Reaction: A Review

Abstract

Knoevenagel condensation reaction is a basic reaction of organic chemistry employed for the construction of C-C double bonds from aromatic carbonyl compounds specially aldehydes or ketones with active methylenes materials using different catalysts and also employed for the total synthesis of natural products, fine chemicals, pharmaceutical products, functional polymers and various important drug intermediates. In this article we discuss some recent developments to catalyze the Knoevenagel condensation reaction of different reactant in different catalytic environment, under different reaction conditions and comparative study of activity of some literate reported catalyst for Knoevenagel condensation reaction. Certainly this review will provide a great help to researchers for the new developments in the field of Knoevenagel condensation.