2005
DOI: 10.1021/cr030040w
|View full text |Cite
|
Sign up to set email alerts
|

Recent Developments in Mass Spectrometry for the Characterization of Nucleosides, Nucleotides, Oligonucleotides, and Nucleic Acids

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

0
92
0
5

Year Published

2005
2005
2014
2014

Publication Types

Select...
8
1

Relationship

0
9

Authors

Journals

citations
Cited by 125 publications
(97 citation statements)
references
References 356 publications
0
92
0
5
Order By: Relevance
“…However in recent times, with the development of LC coupled to MS and on-going technological advances in ionization methods, in particular ESI as well as ion transmission and detection, MS has become a viable method for the quantitation of DNA adducts levels in animal and human samples obtained after exposure to exogenous and endogenous genotoxic compounds. Comprehensive reviews describing the application of LC coupled to MS for the study of DNA adducts have been published by Esmans et al (41)(42)(43)(44)(45). Figure 2 highlights the guanine and phosphate backbone adducts formed in DNA following exposure to various genotoxic chemicals that have been studied using LC-ESI-MS.…”
Section: Mass Spectrometry In the Analysis Of Dna Adductsmentioning
confidence: 99%
“…However in recent times, with the development of LC coupled to MS and on-going technological advances in ionization methods, in particular ESI as well as ion transmission and detection, MS has become a viable method for the quantitation of DNA adducts levels in animal and human samples obtained after exposure to exogenous and endogenous genotoxic compounds. Comprehensive reviews describing the application of LC coupled to MS for the study of DNA adducts have been published by Esmans et al (41)(42)(43)(44)(45). Figure 2 highlights the guanine and phosphate backbone adducts formed in DNA following exposure to various genotoxic chemicals that have been studied using LC-ESI-MS.…”
Section: Mass Spectrometry In the Analysis Of Dna Adductsmentioning
confidence: 99%
“…To properly characterize the products of Cfr modification, we developed an online nanoliquid chromatography electrospray ionization tandem mass spectrometry (nano-LC-ESI-MS n ) approach on an Agilent 6340 ion trap mass spectrometer. Mass spectrometry has successfully been employed in the structural characterization of nucleobases and nucleosides (for reviews, see Crain 1990a;Banoub et al 2005). Mass spectrometric studies of RNA nucleosides involve collisioninduced dissociation (CID) in multiple tandem MS steps (MS n ), which typically commences with neutral loss of ribose followed by a concerted ring opening and elimination of ammonia from the protonated nucleobase.…”
Section: Introductionmentioning
confidence: 99%
“…More detailed descriptions of mass spectrometer configurations, especially as used in small and large molecule biological research, can be found in a number of recent reviews. 4,9,31,[33][34][35]101,102 The most common mass spectrometry platform for nucleoside analysis depends on the analytical goals of the experiment.…”
Section: High-performance Liquid Chromatography -Oligonucleotidesmentioning
confidence: 99%
“…For a more historical description of this area, a number of excellent reviews and book chapters can be consulted. [3][4][5][6][7][8][9][10] When RNA modifications are viewed through the lens of MS, there are essentially 3 different sample types one could analyze: nucleosides and nucleotides (treated in MS as small molecules), oligonucleotides, and intact nucleic acids (the latter 2 both treated as larger biopolymers). Techniques and strategies in small molecule MS -usually arising from developments in organic mass spectrometry -have not only been applied to nucleosides and nucleotides, but also to oligonucleotides.…”
Section: Introductionmentioning
confidence: 99%