Recent developments in microfluidic passive separation to enable purification of platelets for transfusion
Mai T. P. Dinh,
Mubasher Iqbal,
Kumar Abhishek
et al.
Abstract:Platelet transfusion is a lifesaving therapy intended to prevent and treat bleeding. However, in addition to platelets, a typical unit also contains a large volume of supernatant that accumulates multiple pro-inflammatory contaminants, including residual leukocytes, microaggregates, microparticles, antibodies, and cytokines. Infusion of this supernatant is responsible for virtually all adverse reactions to platelet transfusions. Conventional methods for removing residual leukocytes (leukoreduction) and reducin… Show more
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