Recent developments in novel drug delivery systems for wound healing

Abstract

Controlled and localized delivery of wound healing drugs to the wounds is more convenient than systemic administration as higher concentrations of the medication are delivered directly to the desired area in a sustained manner. They are also capable of providing optimum environmental conditions to facilitate wound healing while eliminating the need for frequent changes of dressings. As the number of people suffering from chronic wounds is increasing around the world, controlled delivery of wound healing agents have enormous potential for patient-friendly wound management.

Nanotechnology-Driven Therapeutic Interventions in Wound Healing: Potential Uses and Applications

“…97 For example, liposomes were recently used to facilitate the delivery of madecassoside drug in order to promote cell growth, accelerate cutaneous wound healing, and reduce scar formation. 98 …”

Current status and future outlook of nano‐based systems for burn wound management

“…Re-epithelialization improvement compared with the free drug and increasing the anti-inflamatory activity by downregulation of inflammatory responses has been reported in these systems. This is mainly because of reactive oxygen species (ROS) quenching, which reduces gene expression of glutathione peroxidase and nuclear factor kappa B (NFkB) (Pachuau, 2015). In one study, EGF-loaded PLGA-NPs gave the highest level of fibroblast proliferation and the fastest healing in full-thickness wounds (Yüksel, Karakeçili, Demirtaş, & Gümüşderelio glu, 2016).…”

Anti-Inflammatory and Healing Potential of Phytoderivatives in Cutaneous Rabbits Wounds

“…[19,73] It is interesting to perform a clinical biochemical monitoring procedure throughout the experiment, starting with a serological analysis of the animals on the day of their arrival at the experiment site for an evaluation of their initial hematological profile, and new analyzes every five days for biochemical screening. Sampling on the thirtieth day of the experiment can provide unrealistic results from animal metabolism.…”