Recent developments in persufflation for organ preservation

Min, Catherine G.; Papas, Klearchos K.

doi:10.1097/mot.0000000000000526

Cited by 12 publications

(3 citation statements)

References 65 publications

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“…Recent innovations have focused on expanding the pancreas donor pool, including organs from older donors, those with higher BMI and those recovered from controlled donation after circulatory death (cDCD) [12][13][14]. In this sense, machine perfusion, in its' hypothermic, normothermic or persufflation modalities, could be the key to improving the quality of the donor pancreas as well as the pool of organs available for pancreas and islet transplantation [15,16].…”

Section: Description Of Target Populationmentioning

confidence: 99%

European Society for Organ Transplantation (ESOT) Consensus Statement on the Role of Pancreas Machine Perfusion to Increase the Donor Pool for Beta Cell Replacement Therapy

Ferrer-Fàbrega

Mesnard

Messner³

et al. 2023

Transpl Int

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The advent of Machine Perfusion (MP) as a superior form of preservation and assessment for cold storage of both high-risk kidney’s and the liver presents opportunities in the field of beta-cell replacement. It is yet unknown whether such techniques, when applied to the pancreas, can increase the pool of suitable donor organs as well as ameliorating the effects of ischemia incurred during the retrieval process. Recent experimental models of pancreatic MP appear promising. Applications of MP to the pancreas, needs refinement regarding perfusion protocols and organ viability assessment criteria. To address the “Role of pancreas machine perfusion to increase the donor pool for beta cell replacement,” the European Society for Organ Transplantation (ESOT) assembled a dedicated working group comprising of experts to review literature pertaining to the role of MP as a method of improving donor pancreas quality as well as quantity available for transplant, and to develop guidelines founded on evidence-based reviews in experimental and clinical settings. These were subsequently refined during the Consensus Conference when this took place in Prague.

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Section: Description Of Target Populationmentioning

confidence: 99%

European Society for Organ Transplantation (ESOT) Consensus Statement on the Role of Pancreas Machine Perfusion to Increase the Donor Pool for Beta Cell Replacement Therapy

Ferrer-Fàbrega

Mesnard

Messner³

et al. 2023

Transpl Int

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“…Humidified, gaseous oxygen (or oxygen–nitric oxide gas mixture) is delivered directly to the organ via its vasculature after a period of cold storage. 23 The technique is simple, needing only access to the gas mixture, and cheap, as no organ perfusion circuits are needed. Most preclinical work in liver, kidney, pancreas, and heart show superiority of persufflation over cold storage in DCD settings.…”

mentioning

confidence: 99%

“…Most preclinical work in liver, kidney, pancreas, and heart show superiority of persufflation over cold storage in DCD settings. 23 Clinical experience is limited, and a recent randomized controlled trial in DBD livers did not show superiority of persufflation over cold storage, though there was some suggestion that it might be beneficial for subgroups of high-risk liver grafts. 24 This technique requires further clinical investigation and comparison with HOPE.…”

mentioning

confidence: 99%