Recent developments in quantitative SERS: Moving towards absolute quantification

Towards Reliable and Quantitative Surface‐Enhanced Raman Scattering (SERS): From Key Parameters to Good Analytical Practice

“…Fortunately,E Fv ariations can be mitigated by the addition of as tandard whose response will change in the same way as the target to experimental variations.The target signal can then be normalized to the internal standard signal, see the Review article Ref. [30].T he most obvious internal standards are isotopologues of the target since these will track the variation in the EF of the target very well. [31] Alternatively,chemically similar compounds may be appropriate [32] or standard addition can be used.…”

“…The target signal can then be normalized to the internal standard signal, see the Review article Ref. . The most obvious internal standards are isotopologues of the target since these will track the variation in the EF of the target very well .…”

European analytical column number 47

“…This success is driven by ground-breaking development in instruments and data processing. Recent developments towards quantitative evaluation [5], the combination with fluorescence measurement [6] or imaging result in high citation rates. SERS is used in environmental analytics for the detection of heavy metals.…”

Surface‐enhanced Raman scattering as a tool to study cationic surfactants exhibiting low critical micelle concentration

“…SERS has many advantages over ordinary spectroscopic analytical techniques because of its extremely high sensitivity; even single molecule detection has been reported . However, it is not yet widely used as a standard analytical tool due mainly to the lack of reproducibility and stability of SERS substrates; nevertheless, SERS quantitative measurements are being reported with ever increasing frequency . Hence, SERS could therefore be exploited for the determination of CMC at low micelle concentration detection, where most methods fail.…”

“…[10][11][12] However, it is not yet widely used as a standard analytical tool due mainly to the lack of reproducibility and stability of SERS substrates; nevertheless, SERS quantitative measurements are being reported with ever increasing frequency. [13][14][15][16] Hence, SERS could therefore be exploited for the determination of CMC at low micelle concentration detection, where most methods fail. In this context, ultralow-CMC micelles are anticipated to become the next-generation carriers of drugs with high therapeutic value and to play a pivotal role in clinical drug delivery.…”