Recent developments in solvent-free multicomponent reactions: a perfect synergy for eco-compatible organic synthesis

Synergy Effects in the Chemical Synthesis and Extensions of Multicomponent Reactions (MCRs)—The Low Energy Way to Ultra-Short Syntheses of Tailor-Made Molecules

“…Unconventional solvents [135] such as trifluoroethanol [136] were also investigated. Solvent-free MCRs [137,138] also provide good results.…”

Synthesis and antibacterial activity of 2-amino chromenes arising cyanoiminocoumarins and β-naphthol

“…Among different types of chromene systems, 2-amino-4H-chromenes are of particular utility due to highly pronounced spasmolitic-, diuretic-, anticoagulant-and antianaphylactic activities [7][8][9] . They have also been widely employed as cosmetics, pigments, laser dyes, optical brighteners fluorescence markers and potent biodegradable agrochemicals [10][11][12][13][14] .…”

“…They have also been widely employed as cosmetics, pigments, laser dyes, optical brighteners fluorescence markers and potent biodegradable agrochemicals [10][11][12][13][14] . In addition, they can be used to privileged medicinal scaffolds serving for generation of small-molecule ligands 7 . More specifically, 2-amino-4H-chromene-3-carbonitrile derivatives are of broad pharmaceutical interest and significance because they provide a promising lead for the development of 33 new analogues as potential anti-cancer anticoagulant and antibacterial agents [15][16][17] .…”

Effiecient, Eco-Friendly Sulfamic Acid Catalyzed Synthesis of Bis(6-Aminouracil-5-Yl)methane at Room Temperature

“…All these concerns are directly connected to the goals of "green chemistry" [26][27] . In addition, to the benefits from the economic point of view, recovery and reuse of the catalyst are also important in order to escape wastes, so refining the greenness of the process 28 .…”