Recent developments in the asymmetric synthesis of Р-chiral phosphorus compounds

THERMOGRAVIMETRIC, 31P NMR AND MASS SPECTROMETRIC STUDIES OF Cu(I) AMINOPHOSPHINE COMPLEXES

“…[1][2][3] Phosphines are known to stabilize metal centers in low oxidation state by σ-donation and π-back donation. One of the most attractive features of phosphine ligand is accessibility for tuning their electronic properties and steric profiles by the suitable choice of the substituents on phosphorus.…”

A study on the optical resolution of 1-isopropyl-3-methyl-3-phospholene 1-oxide and its use in the synthesis of borane and platinum complexes

“…Although an increasing number of examples can be found in the literature for the asymmetric syntheses of P-stereogenic compounds [7][8][9], in most cases the resolution of the corresponding racemic compounds is the method of choice for the preparation of optically active organophosphorus compounds including P-heterocyclic derivatives with a Pstereogenic center [6,10]. Many examples can be found in the literature for the resolution of 3 cyclic P-chiral phosphines, phosphine oxides and phosphonium salts via the formation of covalent diasteromers [11][12][13], diastereomeric coordination [14][15][16][17][18][19], molecular complexes [10,20,21] or diastereomeric salts [22][23][24][25][26][27].…”

Biotransformations of 2-hydroxy-2-(ethoxyphenylphosphinyl)acetic acid and the determination of the absolute configuration of all isomers

“…The second method is based on an analysis using chiral solvating agents (CSA), which form complexes with the analysed compound by weak interactions (e.g., hydrogen bonds, Van der Waals forces) [4]. Chiral hydroxyphosphonates are important precursors for the synthesis of a variety of important organophosphates [5][6][7]. Many of the known hydroxyphosphonates not yet been tested for their biological properties, however, are known to have potential antiviral [8], antibacterial [9] and antitumor properties [5].…”