Recent developments in the chiroptical properties of chiral plasmonic gold nanostructures: bioanalytical applications

Advances in Enantiomer-Dependent Nanotherapeutics

“…The result is similar even after including an additional keyword “biomedical”, with the number of studies increasing from “13” to “51” in 2022. It is important to note that after reviewing articles on chiral nanomaterials in biomedical applications, the authors found that most of these articles focused on the study of chirality in bioanalysis, ,, such as biosensors, and in biocatalysts, rather than on chiral nanotherapeutics, suggesting a huge potential in this field.…”

“…Chiral nanostructures have attracted a lot of attention in recent years for biological applications because of the size effect and external response properties of NPs as well as the structure and function of chirality in biological organisms. There have been multiple studies discussing the biological applications of chiral nanostructures, but these have mostly focused on bioanalytical applications such as biocatalysts, biosensing and bioassay. ,,, In this Review, we aim to discuss how chirality in nanostructures can be applied to therapeutics, including cancer therapy, vaccination, and neuronal differentiation.…”

“…Specifically, the chiral ligands selectively bind to the surface of the growing particles, creating a chiral environment that favors the formation of particles with particular handedness. Compared with chiral NPs, nanoassemblies can be (i) assembled via intrinsic chiral interactions; (ii) bound by chiral templates such as peptides and DNA; and (iii) induced by external fields, e.g., based on chiral molecules interacting with circularly polarized photons undergoing circularly polarized effects from the absorption of clockwise and counterclockwise circularly polarized light (CPL) by molecule. , It has been shown that inorganic racemic NPs induce immune activation, and the reason for this can be explained by the existence of inorganic NP interactions with nanoscale chirality and protein–protein nanoscale complexes, which also have mirror image asymmetry, leading to modulation of the immune response . In addition, several studies on chiral nanotherapeutics for cancer, immune modulation, and neurodegenerative diseases have emerged in recent years.…”

Uncovering the Multipolar Contribution for Plasmonic Activity in Multiparticle Metamolecules Manipulated with an Atomic Force Microscope

“…Controlling the alignment of metal nanoparticles and tuning their optical activity are of great significance for exploring the origin and application of plasmonic chirality. Great efforts have been made to tailor the optical response, − such as self-assembly of chiral plasmonic nanostructures, ,− facile hole-mask colloidal lithography, − atomic force microscopy (AFM)-based particle manipulation, , and others. These methods provide the ability to modify the optical activity of nanostructures by tuning the size and alignment of the particles.…”

Optical Resonances of Chiral Metastructures in the Mid‐infrared Spectral Range

“…[27][28][29] Various lithographic techniques have proven to be effective methods of fabricating large arrays of chiral metamaterials. Structures, which were fabricated using either electron beam lithographic techniques, [30][31][32] dimerized gold nanoparticles, [1,33] reconfigurable 3D assemblies, [34] and stacked metamaterials that have demonstrated strong circular dichroism responses in the ultraviolet, visible, near-infrared, and mid-infrared spectral ranges. [35][36][37] If chiral sensing in the mid infrared range is an important application, the possibility to enhanced chiral field opens other opportunities such as polarizing filters as well in the field of plasmon-mediated synthesis where a circularly polarized field could enhance the photoproduction or optical switching of one specific enantiomer.…”