Recent developments in the detection of bovine serum albumin

Jahanban-Esfahlan, Ali; Ostadrahimi, Alireza; Roufegarinejad, Leila; Tabibiazar, Mahnaz; Amarowicz, Ryszard

doi:10.1016/j.ijbiomac.2019.07.096

Cited by 227 publications

(103 citation statements)

References 110 publications

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“…Albumin is a unique pleiotropic protein with a single 585-amino acid polypeptide chain [12]. Albumin is a multifunctional protein that participates in the regulation of colloid osmotic pressure, transportation of endogenous ligands and drugs, and regulation of microvascular permeability [13][14][15]. Furthermore, albumin has been regarded as a potent antioxidant with free radical scavenging activities and a unique biochemical structure [16,17].…”

Section: Introductionmentioning

confidence: 99%

Albumin Reduces Oxidative Stress and Neuronal Apoptosis via the ERK/Nrf2/HO‐1 Pathway after Intracerebral Hemorrhage in Rats

Deng

Liu

Jin

et al. 2021

Oxidative Medicine and Cellular Longevity

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Background. Albumin has been regarded as a potent antioxidant with free radical scavenging activities. Oxidative stress and neuronal apoptosis are responsible for its highly damaging effects on brain injury after intracerebral hemorrhage (ICH). Here, the present study investigated the neuroprotective effect of albumin against early brain injury after ICH and the potential underlying mechanisms. Methods. Adult male Sprague-Dawley rats were subjected to intrastriatal injection of autologous blood to induce ICH. Human serum albumin was given by intravenous injection 1 h after ICH. U0126, an inhibitor of extracellular signal-regulated kinase (ERK1/2), and ML385, an inhibitor of nuclear factor-E2-related factor 2 (Nrf2), were intraperitoneally administered 1 h before ICH induction. Short- and long-term neurobehavioral tests, western blotting, immunofluorescence staining, oxidative stress evaluations, and apoptosis measurements were performed. Results. Endogenous expression of albumin (peaked at 5 days) and heme oxygenase 1 (HO-1, peaked at 24 h) was increased after ICH compared with the sham group. Albumin and HO-1 were colocalized with neurons. Compared with vehicle, albumin treatment significantly improved short- and long-term neurobehavioral deficits and reduced oxidative stress and neuronal death at 72 h after ICH. Moreover, albumin treatment significantly promoted the phosphorylation of ERK1/2; increased the expression of Nrf2, HO-1, and Bcl-2; and downregulated the expression of Romo1 and Bax. U0126 and ML385 abolished the treatment effects of albumin on behavior and protein levels after ICH. Conclusions. Albumin attenuated oxidative stress-related neuronal death may in part via the ERK/Nrf2/HO-1 signaling pathway after ICH in rats. Our study suggests that albumin may be a novel therapeutic method to ameliorate brain injury after ICH.

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Section: Introductionmentioning

confidence: 99%

Albumin Reduces Oxidative Stress and Neuronal Apoptosis via the ERK/Nrf2/HO‐1 Pathway after Intracerebral Hemorrhage in Rats

Deng

Liu

Jin

et al. 2021

Oxidative Medicine and Cellular Longevity

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“…In addition to the optical and electrical properties mentioned above, other factors such as high-quality seed capability and high biocompatibility had made these nanoparticles (NPs) worthy of a variety of applications, such as biosensors, medical imaging, and cancer treatment [7,9,[13][14][15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

“…It contains 585 amino acids and lacks prosthetic groups. HSA has long half-life and can be located on chromosome 4 q (11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22) and ended in anomalous protein with 1691 nucleotide, 14 introns and 15 exons. Other characteristics of HAS are anti-coagulant and antithrombotic functions which leads to delayed aggregation of platelets by binding to Nitric oxide (NO) and inhibiting its inactivation.…”

Section: Introductionmentioning

confidence: 99%

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Improved albumin detection in bovine serum albumin concentration by Au/Ag nanocrystallites

2020

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In the present work, we had used two methods (solvothermal and seed growth methods) to sense albumin concentration based on the optical and plasmonic characteristics of Au/Ag nanocrystallites and their interaction with bovine serum albumin (BSA). They were studied using UV-Vis spectroscopy, transmission electron microscopy (TEM) techniques. The obtained results indicated that the good interactions between nanocrystallites and BSA happen. With the help of changes in plasmonic peaks and comparison of TEM images before and after the interaction for different concentrations of albumin samples, we had obtained a qualitative method of identifying albumin (down to 0.2 mg/ml) concentration.

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“…Various nanocarriers including polymeric nanoparticles such as hydrogeles, dendrimers, polymerosomes, lipid nanocarriers such as liposomes, micelles, organic nanoparticles such as carbon nanotubes, fullerenes, and non-organic nanoparticulates of gold, silver, magnetic Fe 3 O 4 , etc. have often been used for various purposes in the detection and cure of human diseases, in particular, cancer 1–3. Nevertheless, various physiological/physical barriers still need to be addressed in relation to: (i) tumor cell heterogeneity such as clonal evolution and alteration/loss of tumor cell-specific surface markers, (ii) microenvironment of cancer cell such as the presence of a dense extracellular matrix, poor vascular system, low pH, etc., (iii) presence of different physiological barriers such as plasma/nuclear/organelle membranes, blood-brain barrier (BBB), etc; (iv) properties of nanoparticles, including their safety profile, stability, drug encapsulation efficiency, etc 4,5.…”

Section: Introductionmentioning

confidence: 99%

<p>Static DNA Nanostructures For Cancer Theranostics: Recent Progress In Design And Applications</p>

Jahanban-Esfahlan

Seidi

Jaymand

et al. 2019

NSA

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Among the various nano/biomaterials used in cancer treatment, the beauty and benefits of DNA nanocomposites are outstanding. The specificity and programmability of the base pairing of DNA strands, together with their ability to conjugate with different types of functionalities have realized unsurpassed potential for the production of two- and three-dimensional nano-sized structures in any shape, size, surface chemistry and functionality. This review aims to provide an insight into the diversity of static DNA nanodevices, including DNA origami, DNA polyhedra, DNA origami arrays and bioreactors, DNA nanoswitch, DNA nanoflower, hydrogel and dendrimer as young but promising platforms for cancer theranostics. The utility and potential of the individual formats in biomedical science and especially in cancer therapy will be discussed.

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Recent developments in the detection of bovine serum albumin

Cited by 227 publications

References 110 publications

Albumin Reduces Oxidative Stress and Neuronal Apoptosis via the ERK/Nrf2/HO‐1 Pathway after Intracerebral Hemorrhage in Rats

Albumin Reduces Oxidative Stress and Neuronal Apoptosis via the ERK/Nrf2/HO‐1 Pathway after Intracerebral Hemorrhage in Rats

Improved albumin detection in bovine serum albumin concentration by Au/Ag nanocrystallites

<p>Static DNA Nanostructures For Cancer Theranostics: Recent Progress In Design And Applications</p>

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