Recent developments of bioanalytical methods in determination of neurotransmitters in vivo

Matys, Joanna; Gieroba, Barbara; Jóźwiak, Krzysztof

doi:10.1016/j.jpba.2019.113079

Cited by 24 publications

(13 citation statements)

References 105 publications

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“…Consequently, increasing research interest has been noted in overcoming these challenges, and, in recent years, developments have been reported in designing and optimizing tools for the direct detection of chemical biomarkers involved in neurological disorders [ 60 , 90 , 132 , 133 , 134 ]. The diagnosis and detection of NTs in direct and biological samples can be performed using various tools, including electrochemical methods, fluorescence resonance energy transfer, chemiluminescence, various combinations of chromatography, mass spectrometry, and capillary electrophoresis (i.e., GC, HPLC, GC-MS, LC-MS, CE-MS), surface-enhanced Raman spectroscopy, and NIR-based biosensing, and microdialysis methods [ 8 , 135 , 136 , 137 , 138 , 139 ].…”

Section: Neurotransmitters Detectionmentioning

confidence: 99%

Neurotransmitters—Key Factors in Neurological and Neurodegenerative Disorders of the Central Nervous System

Teleanu

Niculescu

Roza

et al. 2022

IJMS

170

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Neurotransmitters are molecules that amplify, transmit, and convert signals in cells, having an essential role in information transmission throughout the nervous system. Hundreds of such chemicals have been discovered in the last century, continuing to be identified and studied concerning their action on brain health. These substances have been observed to influence numerous functions, including emotions, thoughts, memories, learning, and movements. Thus, disturbances in neurotransmitters’ homeostasis started being correlated with a plethora of neurological and neurodegenerative disorders. In this respect, the present paper aims to describe the most important neurotransmitters, broadly classified into canonical (e.g., amino acids, monoamines, acetylcholine, purines, soluble gases, neuropeptides) and noncanonical neurotransmitters (e.g., exosomes, steroids, D-aspartic acid), and explain their link with some of the most relevant neurological conditions. Moreover, a brief overview of the recently developed neurotransmitters’ detection methods is offered, followed by several considerations on the modulation of these substances towards restoring homeostasis.

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Section: Neurotransmitters Detectionmentioning

confidence: 99%

Neurotransmitters—Key Factors in Neurological and Neurodegenerative Disorders of the Central Nervous System

Teleanu

Niculescu

Roza

et al. 2022

IJMS

170

View full text Add to dashboard Cite

show abstract

“…Even though there are more than 100 messenger molecules identified in the neurotransmission process, NTs can be classified into three major types based on their structure, mode of action, and physiological function . The NTs can be classified as either direct or indirect based on their mode of action and as excitatory or inhibitory based on their physiological function .…”

Section: Neurotransmitters and Their Electrochemical Detection Strate...mentioning

confidence: 99%

“…Finally, molecular and gaseous NTs found in the biological system are nitric oxide and H 2 S Scheme shows the classification of the NTs based on their structural composition and the list of diseases associated with deregulation of these NTs. ,, Several research groups have published review articles on the electrochemical strategies for the detection of NTs ,− using biological materials and in vivo methods . Though all these articles give some information on the detection methods of NTs, in this review we have highlighted amine-based NTs and their electrochemical detection methods that have been developed to date employing nanomaterial interfaces.…”

Section: Neurotransmitters and Their Electrochemical Detection Strate...mentioning

confidence: 99%

“…In most of the diseases, several NTs play vital roles. So simultaneous measurement of these NTs at the same site is clinically relevant to understand the disease mechanism, pathophysiology, as well as effective diagnosis. Single NT measurement and quantification may not be sufficient for early and accurate diagnosis, and to treat the disease conditions. , Considerable effects have been made by several research groups for simultaneous analysis of the NTs, which is very challenging when compared to the single NT detection.…”

Section: Simultaneous Analysis Of Ntsmentioning

confidence: 99%

“…■ NEUROTRANSMITTERS AND THEIR ELECTROCHEMICAL DETECTION STRATEGIES Even though there are more than 100 messenger molecules identified in the neurotransmission process, NTs can be classified into three major types based on their structure, mode of action, and physiological function. 37 The NTs can be classified as either direct or indirect based on their mode of action and as excitatory or inhibitory based on their physiological function. 5 However, in this review, we have focused on NT classes based on their chemical structure and detailed the different electrochemical strategies reported for their detection.…”

Section: ■ Typical Neurotransmission Processmentioning

confidence: 99%

See 2 more Smart Citations

“Nano”: An Emerging Avenue in Electrochemical Detection of Neurotransmitters

Madhurantakam

Karnam

Brabazon

et al. 2020

ACS Chem. Neurosci.

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The growing importance of nanomaterials toward the detection of neurotransmitter molecules has been chronicled in this review. Neurotransmitters (NTs) are chemicals that serve as messengers in synaptic transmission and are key players in brain functions. Abnormal levels of NTs are associated with numerous psychotic and neurodegenerative diseases. Therefore, their sensitive and robust detection is of great significance in clinical diagnostics. For more than three decades, electrochemical sensors have made a mark toward clinical detection of NTs. The superiority of these electrochemical sensors lies in their ability to enable sensitive, simple, rapid, and selective determination of analyte molecules while remaining relatively inexpensive. Additionally, these sensors are capable of being integrated in robust, portable, and miniaturized devices to establish point-of-care diagnostic platforms. Nanomaterials have emerged as promising materials with significant implications for electrochemical sensing due to their inherent capability to achieve high surface coverage, superior sensitivity, and rapid response in addition to simple device architecture and miniaturization. Considering the enormous significance of the levels of NTs in biological systems and the advances in sensing ushered in with the integration of nanotechnology in electrochemistry, the analysis of NTs by employing nanomaterials as interface materials in various matrices has emerged as an active area of research. This review explores the advancements made in the field of electrochemical sensors for the sensitive and selective determination of NTs which have been described in the past two decades with a distinctive focus on extremely innovative attribut,es introduced by nanotechnology.

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Analytical strategies in neurotransmitter measurements: A mini literature review

Zhu

Liu

Chen

et al. 2022

Biomedical Chromatography

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Neurotransmitters (NTs) are endogenous, polar, low‐molecular‐weight compounds that play multiple pivotal roles in the central nervous system. NTs are involved in communicating information, responding to stress, regulating motor coordination, and allowing interneuronal communication in living organisms. It is essential to determine the distribution of NTs in brain regions to better understand drug dependence and abuse, neurological disorders, psychological disorders, and aging. Monitoring NT levels is also important in diagnosing and avoiding serious illnesses. We here review chromatography‐based analytical techniques, including pretreatment methods (e.g., microdialysis and solid‐phase microextraction), as well as detection strategies (e.g., MS and electrochemistry), focusing on developments in these techniques over the past 5 years. We then highlight recent advances in electrochemical and fluorescence imaging methods in vivo and the disadvantages and advantages of such technologies, including high spatiotemporal resolution, polymer specificity, and high sensitivity. Finally, we summarize and compare the complementary advantages of chromatography‐based analytical techniques and biosensors and discuss trends in the development of NT detection technologies.

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Recent developments of bioanalytical methods in determination of neurotransmitters in vivo

Cited by 24 publications

References 105 publications

Neurotransmitters—Key Factors in Neurological and Neurodegenerative Disorders of the Central Nervous System

Neurotransmitters—Key Factors in Neurological and Neurodegenerative Disorders of the Central Nervous System

“Nano”: An Emerging Avenue in Electrochemical Detection of Neurotransmitters

Analytical strategies in neurotransmitter measurements: A mini literature review

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