Recent developments of biomaterial scaffolds and regenerative approaches for craniomaxillofacial bone tissue engineering

Gundu, Shravanya; Varshney, Neelima; Sahi, Ajay Kumar; Mahto, Sanjeev Kumar

doi:10.1007/s10965-022-02928-4

Cited by 18 publications

(21 citation statements)

References 185 publications

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“…Synthetic polymers have excellent biocompatibility, biodegradability and have been approved by FDA for clinical applications. , The most popular synthetic polymers for 3D scaffolds are saturated poly(α-hydroxy esters) such as PCL, poly(lactic acid) (PLA), poly( l -lactide) (PLLA), poly(glycolic acid) (PGA), and copolymer poly(lactic- co -glycolic acid) (PLGA) . PLA has high mechanical strength and degrades more rapidly than PCL, but PCL offers more flexibility and easy processability.…”

Section: Biomaterials Employed To Fabricate Scaffolds Suitable For Cm...mentioning

confidence: 99%

Bioactive Scaffolds as a Promising Alternative for Enhancing Critical-Size Bone Defect Regeneration in the Craniomaxillofacial Region

Bello,

Cruz-Lebrón,

Rodríguez-Rivera

et al. 2023

ACS Appl. Bio Mater.

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Reconstruction of critical-size bone defects (CSDs) in the craniomaxillofacial (CMF) region remains challenging. Scaffold-based bone-engineered constructs have been proposed as an alternative to the classical treatments made with autografts and allografts. Scaffolds, a key component of engineered constructs, have been traditionally viewed as biologically passive temporary replacements of deficient bone lacking intrinsic cues to promote osteogenesis. Nowadays, scaffolds are functionalized, giving rise to bioactive scaffolds promoting bone regeneration more effectively than conventional counterparts. This review focuses on the three approaches most used to bioactivate scaffolds: (1) conferring microarchitectural designs or surface nanotopography; (2) loading bioactive molecules; and (3) seeding stem cells on scaffolds, providing relevant examples of in vivo (preclinical and clinical) studies where these methods are employed to enhance CSDs healing in the CMF region. From these, adding bioactive molecules (specifically bone morphogenetic proteins or BMPs) to scaffolds has been the most explored to bioactivate scaffolds. Nevertheless, the downsides of grafting BMP-loaded scaffolds in patients have limited its successful translation into clinics. Despite these drawbacks, scaffolds containing safer, cheaper, and more effective bioactive molecules, combined with stem cells and topographical cues, remain a promising alternative for clinical use to treat CSDs in the CMF complex replacing autografts and allografts.

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Section: Biomaterials Employed To Fabricate Scaffolds Suitable For Cm...mentioning

confidence: 99%

Bioactive Scaffolds as a Promising Alternative for Enhancing Critical-Size Bone Defect Regeneration in the Craniomaxillofacial Region

Bello,

Cruz-Lebrón,

Rodríguez-Rivera

et al. 2023

ACS Appl. Bio Mater.

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“…They must present characteristics such as immunogenicity, availability, low production cost, and resistance to sterilization processes to be considered biodegradable, economical, and promising alternatives for applications in different industrial areas [ 7 ]. The conscious production of biomaterials presents a viable and sustainable alternative for replacing packaging [ 8 ] and textile materials [ 9 ], as well as applications in the areas of biomedicine and dentistry [ 10 , 11 ]. Some biomaterials show biological properties derived from raw material sources.…”

Section: Biomaterialsmentioning

confidence: 99%

The Importance of Antioxidant Biomaterials in Human Health and Technological Innovation: A Review

et al. 2022

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Biomaterials come from natural sources such as animals, plants, fungi, algae, and bacteria, composed mainly of protein, lipid, and carbohydrate molecules. The great diversity of biomaterials makes these compounds promising for developing new products for technological applications. In this sense, antioxidant biomaterials have been developed to exert biological and active functions in the human body and industrial formulations. Furthermore, antioxidant biomaterials come from natural sources, whose components can inhibit reactive oxygen species (ROS). Thus, these materials incorporated with antioxidants, mainly from plant sources, have important effects, such as anti-inflammatory, wound healing, antitumor, and anti-aging, in addition to increasing the shelf-life of products. Aiming at the importance of antioxidant biomaterials in different technological segments as biodegradable, economic, and promising sources, this review presents the main available biomaterials, antioxidant sources, and assigned biological activities. In addition, potential applications in the biomedical and industrial fields are described with a focus on innovative publications found in the literature in the last five years.

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“…The mechanical properties of fibrous PLGA and PLCL allow the formation of biocompatible and fast-bioresorbable scaffolds with a Young’s modulus of 17–22 MPa (PLCL) and 40–55 MPa (PLGA) [ 31 , 32 , 33 , 34 , 35 , 36 , 37 ]. The key challenge in the use of natural and polymeric materials is the difficulty in selecting the optimal balance between the biodegradation rate, mechanical stability, and immune response [ 38 ].…”

Section: Introductionmentioning

confidence: 99%

Biomechanical Behaviors and Degradation Properties of Multilayered Polymer Scaffolds: The Phase Space Method for Bile Duct Design and Bioengineering

et al. 2023

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This article reports the electrospinning technique for the manufacturing of multilayered scaffolds for bile duct tissue engineering based on an inner layer of polycaprolactone (PCL) and an outer layer either of a copolymer of D,L-lactide and glycolide (PLGA) or a copolymer of L-lactide and ε-caprolactone (PLCL). A study of the degradation properties of separate polymers showed that flat PCL samples exhibited the highest resistance to hydrolysis in comparison with PLGA and PLCL. Irrespective of the liquid-phase nature, no significant mass loss of PCL samples was found in 140 days of incubation. The PLCL- and PLGA-based flat samples were more prone to hydrolysis within the same period of time, which was confirmed by the increased loss of mass and a significant reduction of weight-average molecular mass. The study of the mechanical properties of developed multi-layered tubular scaffolds revealed that their strength in the longitudinal and transverse directions was comparable with the values measured for a decellularized bile duct. The strength of three-layered scaffolds declined significantly because of the active degradation of the outer layer made of PLGA. The strength of scaffolds with the PLCL outer layer deteriorated much less with time, both in the axial (p-value = 0.0016) and radial (p-value = 0.0022) directions. A novel method for assessment of the physiological relevance of synthetic scaffolds was developed and named the phase space approach for assessment of physiological relevance. Two-dimensional phase space (elongation modulus and tensile strength) was used for the assessment and visualization of the physiological relevance of scaffolds for bile duct bioengineering. In conclusion, the design of scaffolds for the creation of physiologically relevant tissue-engineered bile ducts should be based not only on biodegradation properties but also on the biomechanical time-related behavior of various compositions of polymers and copolymers.

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Recent developments of biomaterial scaffolds and regenerative approaches for craniomaxillofacial bone tissue engineering

Cited by 18 publications

References 185 publications

Bioactive Scaffolds as a Promising Alternative for Enhancing Critical-Size Bone Defect Regeneration in the Craniomaxillofacial Region

Bioactive Scaffolds as a Promising Alternative for Enhancing Critical-Size Bone Defect Regeneration in the Craniomaxillofacial Region

The Importance of Antioxidant Biomaterials in Human Health and Technological Innovation: A Review

Biomechanical Behaviors and Degradation Properties of Multilayered Polymer Scaffolds: The Phase Space Method for Bile Duct Design and Bioengineering

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