Recent Developments on Ionic Liquids and Deep Eutectic Solvents for Drug Delivery Applications

Qader, Idrees B.; Prasad, Kamalesh

doi:10.1007/s11095-022-03315-w

Cited by 39 publications

(18 citation statements)

References 89 publications

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“…Therefore, two molecules of HBDs are required to form the eutectic to complex with QASs through the chloride ion. This is the same as was observed for preparation of DESs from aspirin, paracetamol, phenol, 2-methyl phenol, 3,4-dimethyl phenol, and benzoic acid with ChCl as QAS. , …”

Section: Resultsmentioning

confidence: 98%

“…In this study, rosemary ( Rosmarinus officinalis ) was used as an example to apply a novel extraction approach, the novelty of which is that a solid QAS is used with the aim of forming a deep eutectic mixture in situ with the endogenous HBDs present in the natural material. The same process has been carried out using fruits, barks, and roots with a similar effect …”

Section: Resultsmentioning

confidence: 99%

“…This is the same as was observed for preparation of DESs from aspirin, paracetamol, phenol, 2-methyl phenol, 3,4-dimethyl phenol, and benzoic acid with ChCl as QAS. 25,26 The eutectic composition occurs at 2 (QAS):1 (HBD) for the HBDs including more than two hydroxyl groups, namely, ascorbic acid, resveratrol, caffeic acid, quercetin, and rosmarinic acid. Therefore, one molecule of HBD is required to form the eutectic mixture to complex with two molecules of QAS.…”

Section: ■ Materials and Methodsmentioning

confidence: 99%

“…The same process has been carried out using fruits, barks, and roots with a similar effect. 32 The mixtures of these biomasses and QAS were kept in an oven at 50 °C for 72 h. The ideal scenario would have been that the natural products would spontaneously form a liquid deep eutectic mixture with the QAS. This was not the case as solid-state interactions are slow.…”

Section: ■ Materials and Methodsmentioning

confidence: 99%

See 3 more Smart Citations

Selective Extraction of Antioxidants by Formation of a Deep Eutectic Mixture through Mechanical Mixing

Qader

Laguerre

Lavaud

et al. 2023

ACS Sustainable Chem. Eng.

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Extraction of active compounds from natural materials is commonly used to produce a diverse range of ingredients, nutrients, drugs, flavors, and fragrances. While solventbased approaches are standard for these extraction procedures, large solvent volumes, greenhouse gas emission (due to atmospheric release of volatile organic compounds), and large energy requirements are significant issues. Here, we describe a novel process wherein a mechanical action is applied to a solid-state mixture comprising a quaternary ammonium salt and a biological material containing active molecules to form a deep eutectic mixture. It is first shown that eutectic mixtures can be formed for a wide range of naturally occurring compounds. Selective extraction of these compounds from natural products is then demonstrated using rosemary leaves with three different quaternary ammonium salts. The eutectic mixture formed is purified by liquid/liquid extraction using an oily phase to concentrate the active constituents in the deep eutectic phase. The resulting natural extracts are shown to exhibit high antioxidant activities, which were measured using the conjugated autoxidizable triene (CAT) and the oxygen radical absorbance capacity (ORAC) assays.

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Section: Resultsmentioning

confidence: 98%

Section: Resultsmentioning

confidence: 99%

Section: ■ Materials and Methodsmentioning

confidence: 99%

Section: ■ Materials and Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Selective Extraction of Antioxidants by Formation of a Deep Eutectic Mixture through Mechanical Mixing

Qader

Laguerre

Lavaud

et al. 2023

ACS Sustainable Chem. Eng.

Self Cite

View full text Add to dashboard Cite

show abstract

“…The possibility of availing materials with physical properties tailored to a specific application has been key for using them in other applications, such as stabilization and activation of biocatalysts, biomass treatment processes, synthesis of biopolymer-based hydrogels, bioseparation processes, environmental problem solving or the development of new ILs from natural products [7]. More specifically, in biomedicine and the pharmaceutical industry, important advances have also been made in the formulation of advanced materials for the generation of artificial tissues [8], drug transport or the formulation of active pharmaceutical ingredients [9,10], enzyme stabilization [11], biocides [12], etc. These applications are only a small sample of the potential of these materials and the importance of research in future applications.…”

Section: Introductionmentioning

confidence: 99%

Influence of Metal Salts Addition on Physical and Electrochemical Properties of Ethyl and Propylammonium Nitrate

Ausín

Trenzado

Turmine

et al. 2022

IJMS

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In this work, we deepen in the characterization of two protic ionic liquids (PILs), ethylammonium nitrate (EAN) and propylammonium nitrate (PAN). With this aim, we determined the influence of inorganic nitrate salts addition on their physical properties and their electrochemical potential window (EPW). Thus, experimental measurements of electrical conductivity, density, viscosity, refractive index and surface tension of mixtures of {EAN or PAN + LiNO3, Ca(NO3)2, Mg(NO3)2 or Al(NO3)3} at a temperature range between 5 and 95 °C are presented first, except for the last two properties which were measured at 25 °C. In the second part, the corresponding EPWs were determined at 25 °C by linear sweep voltammetry using three different electrochemical cells. Effect of the salt addition was associated mainly with the metal cation characteristics, so, generally, LiNO3 showed the lower influence, followed by Ca(NO3)2, Mg(NO3)2 or Al(NO3)3. The results obtained for the EAN + LiNO3 mixtures, along with those from a previous work, allowed us to develop novel predictive equations for most of the presented physical properties as functions of the lithium salt concentration, the temperature and the water content. Electrochemical results showed that a general order of EPW can be established for both PILs, although exceptions related to measurement conditions and the properties of the mixtures were found.

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Designer Solvents for Pharmaceutics: Role of Ionic Liquids/ Deep Eutectic Solvents in Pharmaceutical Formulations

Dhiman,

Alhammadi,

Kim

et al. 2024

Advanced Therapeutics

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The design of biologic and synthetic drugs in the pharmaceutical industry is facing three key challenges, namely, ensuring bioavailability, solubility, and stability. Ionic liquids (ILs) and deep eutectic solvents (DESs), classified as designer solvents, have emerged as excellent solvents for improving the permeability and stability of biotherapeutic drugs. Moreover, they have shown remarkable solubilizing effects for synthetic drugs, particularly in solubilizing active pharmaceutical ingredients (API), and are known as eco‐friendly solvents. Thus, in this review, the development of designer formulations in pharmaceutical industries is reported, and the underlying strategies for designing the most efficient formulations for both biotherapeutics and synthetic drugs are examined.

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Recent Developments on Ionic Liquids and Deep Eutectic Solvents for Drug Delivery Applications

Cited by 39 publications

References 89 publications

Selective Extraction of Antioxidants by Formation of a Deep Eutectic Mixture through Mechanical Mixing

Selective Extraction of Antioxidants by Formation of a Deep Eutectic Mixture through Mechanical Mixing

Influence of Metal Salts Addition on Physical and Electrochemical Properties of Ethyl and Propylammonium Nitrate

Designer Solvents for Pharmaceutics: Role of Ionic Liquids/ Deep Eutectic Solvents in Pharmaceutical Formulations

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