Recent Evaluation of Prognostic Risk Factors in Esophageal Atresia - A Multicenter Review of 223 Cases

Am, Rokitansky; Va, Kolankaya; Seidl, S.; Mayr, J.; Bichler, B.; Schreiner, Wolfgang; Engels, Megan; Horcher, Ernst; Lischka, A; Menardi, G

doi:10.1055/s-2008-1063542

Cited by 26 publications

(9 citation statements)

References 8 publications

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“…The incidence of chromosomal abnormalities and VACTERL association remained similar and unchanged over time in our study as reported by Tönz et al [4], but in contrast to our findings they did not show any increase in the presence of major cardiac anomalies. Other patient characteristics such as sex ratio, birth weight, gestational age and type of atresia are comparable with other reports [4,5,[13][14][15]. Several risk factors have previously been identified for the outcome in patients with EA.…”

Section: Discussionsupporting

confidence: 80%

Outcome in neonates with esophageal atresia treated over the last 20 years

Lilja

Wester

2008

Pediatr Surg Int

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We evaluated the outcome in infants with esophageal atresia (EA) treated in our department over the last two decades. The medical records of 147 infants treated from 1986 to 2005 were reviewed. Patient characteristics, associated anomalies, surgery and complications were recorded. We divided the material into two time-periods: 1986-1995 and 1996-2005; 125 patients or parents were interviewed regarding gastrointestinal function, respiratory symptoms and education. The incidence of major cardiac defects increased from 23 to 29% and the overall survival increased from 87 to 94%. Using Spitz' classification survival increased from 93.5 to 100% in group I and from 68.4 to 77.8% in group II. In group III, during the second time period, survival was 100% in three patients. The incidence of anastomotic leakage and recurrent fistula did not change over time. The rate of anastomotic strictures increased from 53 to 59% between the two time-periods. A primary anastomosis could be done in 85% of the patients during the second period versus 78% of the patients during the first period. Anti-reflux surgery was done in only 11 and 9%, respectively, during the two time-periods. In patients who were 16-20 years old, 40-50% had gastrointestinal and respiratory symptoms. Ninety percent of the patients attended normal school. The major difference between the periods 1986-1995 and 1996-2005 was an increased survival despite an increased incidence of major cardiac defects. Gastrointestinal and respiratory symptoms were frequent. Long-term follow-up and treatment of complications of esophageal atresia is important for this patient group.

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Section: Discussionsupporting

confidence: 80%

Outcome in neonates with esophageal atresia treated over the last 20 years

Lilja

Wester

2008

Pediatr Surg Int

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“…Remarkably, only one randomized control trial 18 and seven prospective studies 3,12-17 could be included in this study. A limited number of multicenter studies 1,3,12,13,21,39,[45][46][47][48] reported on their experiences, whereas the majority presented single center data. Likewise, also comparative studies were rare.…”

Section: Discussionmentioning

confidence: 99%

State of Play: Eight Decades of Surgery for Esophageal Atresia

et al. 2018

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“…Studies have shown that the mortality rate is double in cases which have associated anomalies. [3,6] Iuchtman M et al, also showed 24% more mortality rate in cases with associated anomalies, than without any anomalies. [18] In our study group, survival rate was 88.9%, 90%, 75% and 18%, respectively, for no associated anomalies, single associated anomaly, two associated anomalies and >2 associated anomalies, with an overall survival of 79.7%.…”

Section: Discussionmentioning

confidence: 95%