Recent green approaches for the synthesis of pyrazolo[3,4‐d]pyrimidines: A mini review

Abstract

Pyrazolo [3,4-d]pyrimidine as a bioisostere of purine has drawn considerable attention as a privileged scaffold for the design and discovery of novel drugs. Green synthesis is an emerging area in the field of chemistry that provides economic and environmental benefits as an alternative to traditional methods. The present mini review reflects recent advances in the green synthesis of pyrazolo [3,4-d]pyrimidines,

Pyrazolo[3,4‐d]pyrimidine‐based scaffolds as antibacterial agents: Synthetic strategies, reactions, and in vitro biological evaluation

“…Noteworthy, pyrazolo[3,4‐ d ]pyrimidines emerged as vital pharmaceutically relevant molecules in view of their presence as part of several approved marketed drugs such as parsaclisib, ibrutinib (Imbruvica), allopurinol (Zyloric), umbralisib (Ukoniq). [ 21 ]…”

“…[20] Noteworthy, pyrazolo [3,4-d]pyrimidines emerged as vital pharmaceutically relevant molecules in view of their presence as part of several approved marketed drugs such as parsaclisib, ibrutinib (Imbruvica), allopurinol (Zyloric), umbralisib (Ukoniq). [21] 2 | RESULTS AND DISCUSSION Encouraged by the above-mentioned facts and as a part of our ongoing endeavors to develop valuable heterocyclic building blocks, [22,23] feasible and straightforward synthetic routes were utilized to assemble novel fused and attached pyrazolo [3,4-d]pyrimidine derivatives, aiming to promote their synthetic potential and investigate the associated biological activities.…”