Recent influenza B viruses in Europe: a phylogenetic analysis

Ikonen, Niina; Kinnunen, Leena; Forsten, T.; Pyhälä, Riikka

doi:10.1016/0928-0197(96)00201-2

Cited by 8 publications

(6 citation statements)

References 20 publications

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“…Sequence comparisons of the HAs from the two dominant influenza B lineages in circulation have revealed a number of naturally occurring amino acid substitutions that cluster within their binding pocket (Krystal et al, 1982;Krystal et al, 1983;Kanegae et al, 1990;Ikonen et al, 1996;Nerome et al, 1998;McCullers et al, 1999;McCullers et al, 2004). To assess the impact of these variations on receptor binding affinity, our group examined the receptor binding characteristics of three MDCKpropagated influenza B regional variants corresponding to either the B/Victoria/2/1987 (B/Brisbane/60/2008 and B/Malaysia/2506/ 2004) or B/Yamagata/16/88 (B/Florida/4/2006) lineage (Carbone et al, 2013).…”

Section: Receptor Binding Characteristics Of Influenza B Hemagglutinimentioning

confidence: 99%

The specificity of the influenza B virus hemagglutinin receptor binding pocket: what does it bind to?

Velkov

2013

J of Molecular Recognition

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The influenza surface glycoprotein hemagglutinin (HA) binds to sialylglycoproteins and sialylglycolipids on the surface of host cells. These sialyl-glycans, usually linked to galactose in either α2,6 or α2,3 configurations, are the receptors for the viral HA, the binding to which promotes viral attachment, membrane fusion, and internalization of the virus. This review examines all of the available receptor binding data on the influenza B HA and provides a structure recognition perspective for the receptor binding preferences of influenza B virus HA regional and egg-adapted variants. Overall, the review serves as an up-to-date compendium of the literature binding data, and the presented discussions assist the reader in reaching a consensus understanding of the receptor specificity determinants for the influenza B HA.

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Section: Receptor Binding Characteristics Of Influenza B Hemagglutinimentioning

confidence: 99%

The specificity of the influenza B virus hemagglutinin receptor binding pocket: what does it bind to?

Velkov

2013

J of Molecular Recognition

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“…More extensive NPAs were collected as part of vaccine investigations in the Pori Brigade, where these specimens were taken from 59 of the 522 URI patients (11 . 3 %) noted during the continuous 15-week observation period (weeks [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16]2003). With these measures a total of 299 NPAs were collected during the 6-month study period in 2002/ 2003 from 13 garrisons and one military hospital (referred to as military units hereafter).…”

Section: Virological Surveillancementioning

confidence: 99%

“…The last intense outbreak of Victoria-lineage virus in Finland occurred during 1987/1988 [7]. After low-intensity local outbreaks due to these viruses in 1989/1990 [8], the first outbreak of Yamagata-lineage virus occurred in Finland in 1990/ 1991 [9]. The global re-emergence of the Victorialineage viruses from East Asia in 2001/2002 resulted in a change in the recommended composition of influenza virus vaccines for use in autumn 2002, when a B/Hong Kong/330/2001-like virus (B/Shangdong/7/ 97) was substituted for the B/Sichuan/379/99-like vaccine virus [10].…”

Section: Introductionmentioning

confidence: 99%

Reappearance of influenza B/Victoria/2/87-lineage viruses: epidemic activity, genetic diversity and vaccination efficacy in the Finnish Defence Forces

et al. 2005

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A new B/Shangdong/7/97-like influenza virus (Victoria/2/87 lineage) predominated during the 2002/2003 epidemic season in Finland and was estimated to account for 2246 of the 13,496 feverish upper respiratory tract infections (URIs) occurring among conscripts in the Finnish army. The incidence (1716/10,000 conscripts) was indicative of moderate epidemic activity at most. Analysis of the cross-reactive antibodies induced in 1988 suggests that the basis of the protection was probably established during the childhood of the conscripts. Vaccination in autumn 2002 prevented 42% of the URIs during the influenza B outbreak and 71% (95% CI 42-85) of infections interpreted as influenza B. Despite the low genetic variability of the Shangdong/7/97-like viruses, breakages of a potential glycosylation site in haemagglutinin (HA1, position 197) were frequent; their biological significance is discussed. The Shangdong/7/97-like strains were HA1/NA reassortants, as were also the less abundant strains that for HA1 belonged to the B/Yamagata/16/88 lineage. A further reassortment, which probably emerged during the outbreak in one of the garrisons, supports our hypothesis that circumstances in these settings may especially favour the emergence of diversity by reassortment.

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“…To monitor the emergence of new variants or new subtypes of influenza viruses, isolates across the world are tested for changes in the HA antigen by either serological (hemagglutination inhibition [HI] assay) or genetic (PCR and sequence analysis) means (1,3,4). Some strains are also tested for changes in the neuraminidase antigen (11).…”

mentioning

confidence: 99%

Identification of New Influenza B Virus Variants by Multiplex Reverse Transcription-PCR and the Heteroduplex Mobility Assay

1998

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A quick genetic approach for the screening of influenza virus variants was developed in this laboratory (S. Zou, J. Clin. Microbiol. 35:2623–2627, 1997). It uses multiplex reverse transcription and multiplex PCR to amplify and differentiate the variable region of the hemagglutinin genes of different types and subtypes of influenza viruses. Variants within the same type or subtype are then identified by the heteroduplex mobility shift assay of the amplicons. The method was used to screen influenza virus isolates received from provincial laboratories during the 1996–1997 season and was able to identify new influenza B virus variants. Sequencing of the amplicons derived from the hemagglutinin gene of the identified variants and comparison with the vaccine strain B/Harbin/7/94 showed substitution rates of 2.26 to 2.55% at the nucleotide level and 4.26 to 4.68% at the amino acid level. The result further demonstrated that the approach provides a quick, sensitive, and reliable screening for influenza virus variants. It also suggested the necessity of close monitoring of influenza B virus isolates in the 1997–1998 season and critical evaluation of the reference strain for the type B influenza virus.

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Recent influenza B viruses in Europe: a phylogenetic analysis

Cited by 8 publications

References 20 publications

The specificity of the influenza B virus hemagglutinin receptor binding pocket: what does it bind to?

The specificity of the influenza B virus hemagglutinin receptor binding pocket: what does it bind to?

Reappearance of influenza B/Victoria/2/87-lineage viruses: epidemic activity, genetic diversity and vaccination efficacy in the Finnish Defence Forces

Identification of New Influenza B Virus Variants by Multiplex Reverse Transcription-PCR and the Heteroduplex Mobility Assay

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