Recent Information on Vitamin D Deficiency in an Adult Korean Population Visiting Local Clinics and Hospitals

Choi, Rihwa; Lee, Sang Gon

doi:10.3390/nu14091978

Cited by 11 publications

(10 citation statements)

References 20 publications

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“…Our study showed that only 3% of subjects had vitamin D below 10 ng/mL, 10% had below 15 ng/mL, 22% had below 20 ng/mL, and 42% had below 30 ng/mL. This is in comparison to a very recent large study (180,289 subjects), in which the overall prevalence of vitamin D deficiency status based on 25(OH)D level was as follows: 0.4% for <5 ng/mL, 12.5% for <10 ng/mL, 20.6% for <12 ng/mL, 49.4% for <20 ng/mL, and <75.3% for <30 ng/mL [ 21 ]. Furthermore, Figure 1 , Figure 2 and Figure 3 show the data in graphical presentations that suggest that the levels of vitamin D, PTH, and ALK are skewed to the left.…”

Section: Resultscontrasting

confidence: 48%

The Effect of Vitamin D Level on Parathyroid Hormone and Alkaline Phosphatase

Rajab

2022

Diagnostics

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Over the years, we have noticed in our clinical practice that patients with 25-hydroxyvitamin D (25OHD) levels below 15 ng/mL are more symptomatic than those with higher levels. The aim of this research is to investigate changes in both parathyroid hormone (PTH) and alkaline phosphatase (ALP) at different vitamin D levels to determine if lower vitamin D levels are associated with more severe changes in PTH and ALP, which may explain the presence and severity of symptoms at those lower 25OHD levels. We looked for correlations between 25OHD level, PTH, and ALP in 1311 samples between 2015 and 2019 at our endocrine clinic to determine if vitamin D level correlates with changes in PTH and ALP. We further categorized vitamin D deficiency levels into three categories based on the severity of the reported symptoms. As expected, there were inverse but significant correlations between 25OHD, PTH, and ALP. The lower the 25OHD, the higher the PTH and ALP levels. When 25OHD was below 10 ng/mL, PTH was increased in 65% of the samples and ALP was elevated in 21% of the samples; however, PTH and ALP were normal in 70% and 87%, respectively, of patients with 25OHD levels between 15 < 20 ng/mL. The results support our clinical observations since most of the patients with 25OHD greater than 15 ng/mL had normal PTH and ALP, which may explain the lack of symptoms in these patients.

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Section: Resultscontrasting

confidence: 48%

The Effect of Vitamin D Level on Parathyroid Hormone and Alkaline Phosphatase

Rajab

2022

Diagnostics

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“…Therefore, around one-third of the patients opt for alternative therapies [5]. Since vitamin D deficiency is a common condition [6][7][8][9] associated with cardiovascular disease (CVD) [10], cancer [11], insulin resistance [12][13][14], and other chronic diseases [15], investigators have sought to identify possible associations of vitamin D deficiency with IBS. Therefore, studies have shown an improvement of IBS symptoms with the administration of vitamin D [16,17], an agent playing a critical role in calcium and phosphorous metabolism and homeostasis as well as anti-inflammatory and immunomodulatory activities [18].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Vitamin D Supplementation on the Severity of Symptoms and the Quality of Life in Irritable Bowel Syndrome Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Abuelazm

Shoaib²,

Gamal

et al. 2022

Nutrients

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Irritable bowel syndrome (IBS), a gastrointestinal disorder affecting 7–12% of the population, is characterized by abdominal pain, bloating, and alternating bowel patterns. Data on risk and protective influences have yielded conflicting evidence on the effects of alternative interventions, such as vitamin D. This review focuses on the effects of vitamin D on IBS. A systematic review and meta-analysis considered all articles published until 4 April 2022. The search for randomized controlled trials assessing vitamin D efficacy in IBS with outcomes, primary (Irritable Bowel Severity Scoring System (IBS-SSS)) and secondary (IBS quality of life (IBS-QoL) and serum level of calcifediol (25(OH)D)), was performed on six databases, Google Scholar, Web of Science, SCOPUS, EMBASE, PubMed (MEDLINE), and Cochrane Central Register of Controlled Trials. We included six trials with 616 patients. The pooled analysis found no difference between vitamin D and placebo in improving IBS-SSS (MD: −45.82 with 95% CI [−93.62, 1.98], p = 0.06). However, the pooled analysis favored vitamin D over placebo in improving the IBS-Qol (MD: 6.19 with 95% CI [0.35, 12.03], p = 0.04) and serum 25(OH)D (MD: 25.2 with 95% CI [18.41, 31.98], p = 0.00001). Therefore, further clinical trials are required to reach clinically applicable and generalizable findings.

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“…However, the largest group of patients managed for IDA using ICD-10 D50 was comparable to the number of subjects in this study at Green Cross Laboratories. Considering that Green Cross Laboratories is a referral laboratory for local clinics and hospitals without their own clinical laboratories, and that older patients and those with comorbidities visit university hospitals and medical centers more frequently than others, the differences in patient population characteristics observed in this study may be due to the healthcare-related behaviors of patients [ 21 ]. In addition, the number of patients from the HIRA database includes repeated data from some subjects, which may lead to overestimates of utilization in specific age groups.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Iron Deficiency Anemia Indicated for Intravenous Iron Treatment in the Korean Population

et al. 2023

Self Cite

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We aimed to investigate the number and prevalence of patients indicated for intravenous iron treatment in a large Korean population using criteria based on laboratory test results in an effort to extract indirect information on the need for intravenous iron treatment. Between 1 January 2019 and 31 December 2021, a total of 83,994 Korean patients (30,499 men and 53,495 women) with a median age of 46 years (interquartile range, 30–61) were evaluated using iron deficiency anemia–associated laboratory tests and serum creatinine tests of estimated glomerular filtration rates. The overall prevalence of anemia (Hb ≤ 11 g/dL) was 16.5%, and the proportion of patients with possible chronic kidney disease who had an estimated glomerular filtration rate < 60 mL/min/1.73 m2 was 11.4%. The number of patients indicated for reimbursable intravenous iron treatment was higher in women than in men, higher in older patients, and higher in 2021 than in 2019 (all p < 0.001). The prevalence of patients indicated for reimbursable intravenous iron treatment was up to 30.0% in those ≥ 80 years of age in 2019. The results of this study provide basic knowledge about the use of iron deficiency anemia-associated laboratory tests in planning nutritional support programs using an intravenous iron formulation in Korea.

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Recent Information on Vitamin D Deficiency in an Adult Korean Population Visiting Local Clinics and Hospitals

Cited by 11 publications

References 20 publications

The Effect of Vitamin D Level on Parathyroid Hormone and Alkaline Phosphatase

The Effect of Vitamin D Level on Parathyroid Hormone and Alkaline Phosphatase

The Effect of Vitamin D Supplementation on the Severity of Symptoms and the Quality of Life in Irritable Bowel Syndrome Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Prevalence of Iron Deficiency Anemia Indicated for Intravenous Iron Treatment in the Korean Population

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