Recent Innovations in Bacterial Infection Detection and Treatment

Deusenbery, Carly; Wang, Yingying; Shukla, Anita

doi:10.1021/acsinfecdis.0c00890

Cited by 149 publications

(95 citation statements)

References 263 publications

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“…The LOD of a biosensor is defined as the lowest quantity of a material that can be discerned from a sample lacking the analyte within a defined level of confidence. [26,27] The physicochemical properties of nanostructures, which will be described in this review, can directly influence the attainable LOD. For example, it has been shown that the size and shape of nanostructured electrodes can found to affect total analyte flux and binding.…”

Section: Overview Of Biosensors and Nanostructure Fabricationmentioning

confidence: 99%

Advances in Biosensors and Diagnostic Technologies Using Nanostructures and Nanomaterials

Welch

Powell

Clevinger

et al. 2021

Adv Funct Materials

Self Cite

114

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Nanoscale materials have unique properties that make them especially useful for biomedical diagnostic applications. Recent developments in nanoengineering have resulted in increasing use of nanostructures in biosensors. Various types of 0D, 1D, 2D, and 3D nanostructures have been used to improve biosensor sensitivity, selectivity, limit of detection, and time to result, among other metrics. These nanostructures have been integrated into electrochemical, optical, and other biosensors for this purpose. Here, the most recent advances in the use of nanostructured materials in biosensors are described. This includes a discussion of nanoparticles, nanorods, nanofibers, nanopillars, nanowires, nanosheets, indented nanopatterns (nanoholes and nanoslits), nanogaps, nanochannels, nanopores, nanofunctionalized surfaces, and complex hierarchical structures and their unique advantages and applications in biosensors. Clinical applications of these nanobiosensors are also highlighted along with a discussion of the future directions for these materials in diagnostics.

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Section: Overview Of Biosensors and Nanostructure Fabricationmentioning

confidence: 99%

Advances in Biosensors and Diagnostic Technologies Using Nanostructures and Nanomaterials

Welch

Powell

Clevinger

et al. 2021

Adv Funct Materials

Self Cite

114

View full text Add to dashboard Cite

show abstract

“…Then, we critically review commercial tests and the recent literature for biosensors based on micro-and nanostructured materials aimed at measuring biomarkers and circulating pathogens, and propose different points of the healthcare chain where they could improve sepsis care. Methods for pathogen identification samples other than blood and for determining their susceptibility to antibiotics have been recently reviewed elsewhere [10][11][12]. We finalize by discussing the relevance of micro-and nanostructured materials for developing sepsis biosensors and proposing future advancements for the field.…”

Section: Introductionmentioning

confidence: 99%

Micro- and nanosensors for detecting blood pathogens and biomarkers at different points of sepsis care

et al. 2022

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Severe infections can cause a dysregulated response leading to organ dysfunction known as sepsis. Sepsis can be lethal if not identified and treated right away. This requires measuring biomarkers and pathogens rapidly at the different points where sepsis care is provided. Current commercial approaches for sepsis diagnosis are not fast, sensitive, and/or specific enough for meeting this medical challenge. In this article, we review recent advances in the development of diagnostic tools for sepsis management based on micro- and nanostructured materials. We start with a brief introduction to the most popular biomarkers for sepsis diagnosis (lactate, procalcitonin, cytokines, C-reactive protein, and other emerging protein and non-protein biomarkers including miRNAs and cell-based assays) and methods for detecting bacteremia. We then highlight the role of nano- and microstructured materials in developing biosensors for detecting them taking into consideration the particular needs of every point of sepsis care (e.g., ultrafast detection of multiple protein biomarkers for diagnosing in triage , emergency room, ward, and intensive care unit; quantitative detection to de-escalate treatment; ultrasensitive and culture-independent detection of blood pathogens for personalized antimicrobial therapies; robust, portable, and web-connected biomarker tests outside the hospital). We conclude with an overview of the most utilized nano- and microstructured materials used thus far for solving issues related to sepsis diagnosis and point to new challenges for future development. Graphical abstract Supplementary Information The online version contains supplementary material available at 10.1007/s00604-022-05171-2.

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“…[ 3,4 ] Many techniques including enzyme‐linked immunosorbent assay, polymerase chain reaction, DNA chip, microfluidic analysis, nuclear acid sequence‐based amplification, and microcolony method have been developed for the detection of pathogenic bacteria, fungi, and viruses. [ 5–7 ] However, these techniques have several limitations and disadvantages, such as instrumental dependence, complicated operation, high cost, and time‐consuming process. The effective ablation of pathogenic bacteria, fungi, and viruses is the ultimate goal.…”

Section: Introductionmentioning

confidence: 99%

Aggregation‐Induced Emission‐Based Platforms for the Treatment of Bacteria, Fungi, and Viruses

Chen

Han

Tang

et al. 2021

Adv Healthcare Materials

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The prevention and control of pathogenic bacteria, fungi, and viruses is a herculean task for all the countries since they greatly threaten global public health. Rapid detection and effective elimination of these pathogens is crucial for the treatment of related diseases. It is urgently demanded to develop new diagnostic and therapeutic strategies to combat bacteria, fungi, and viruses‐induced infections. The emergence of aggregation‐induced emission (AIE) luminogens (AIEgens) is a revolutionary breakthrough for the treatment of many diseases, including pathogenic infections. In this review, the main focus is on the applications of AIEgens for theranostic treatment of pathogenic bacteria, fungi, and viruses. Due to the AIE characteristic, AIEgens are promising fluorescent probes for the detection of bacteria, fungi, and viruses with excellent sensitivity and photostability. Moreover, AIEgen‐based theranostic platforms can be fabricated by introducing bactericidal moieties or designing AIE photosensitizers and AIE photothermal agents. The current strategies and ongoing developments of AIEgens for the treatment of pathogenic bacteria, fungi, and viruses will be discussed in detail.

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Recent Innovations in Bacterial Infection Detection and Treatment

Cited by 149 publications

References 263 publications

Advances in Biosensors and Diagnostic Technologies Using Nanostructures and Nanomaterials

Advances in Biosensors and Diagnostic Technologies Using Nanostructures and Nanomaterials

Micro- and nanosensors for detecting blood pathogens and biomarkers at different points of sepsis care

Aggregation‐Induced Emission‐Based Platforms for the Treatment of Bacteria, Fungi, and Viruses

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