2023
DOI: 10.3390/ijms24076180
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Recent Insight into the Role of Sphingosine-1-Phosphate Lyase in Neurodegeneration

Abstract: Sphingosine-1-phosphate lyase (SPL) is a pyridoxal 5′-phosphate-dependent enzyme involved in the irreversible degradation of sphingosine-1-phosphate (S1P)—a bioactive sphingolipid that modulates a broad range of biological processes (cell proliferation, migration, differentiation and survival; mitochondrial functioning; and gene expression). Although SPL activity leads to a decrease in the available pool of S1P in the cell, at the same time, hexadecenal and phosphoethanolamine, compounds with potential biologi… Show more

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Cited by 4 publications
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