Recent insights into human bronchial proteomics – how are we progressing and what is next?

Tan, Heng Wee; Xu, Yan‐Ming; Wu, Dandan; Lau, Andy T. Y.

doi:10.1080/14789450.2017.1417847

Cited by 13 publications

(10 citation statements)

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“…The compound produced noticeable anti-proliferative activities against three oral cancer cell lines (HSC-3, HSC-4, and SAS) at a concentration of 5-100 µM on treatment for 2-5 days (Endo et al 2017). Sodium selenite was found to be efficiently inhibiting the cell proliferation of several types of cancer cells even the deadliest cancer in worldwide, the lung cancer cells too (Tan et al 2018). Among different human cancer cell lines tested, lung cancer cells, in general, appeared to be especially sensitive to selenite (Berthier et al 2017;Lipinski 2017;Chen et al 2018a, b).…”

Section: Inorganic Selenium Compoundsmentioning

confidence: 98%

Selenium and selenoproteins: it’s role in regulation of inflammation

2020

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Selenium is an essential immunonutrient which holds the human's metabolic activity with its chemical bonds. The organic forms of selenium naturally present in human body are selenocysteine and selenoproteins. These forms have a unique way of synthesis and translational coding. Selenoproteins act as antioxidant warriors for thyroid regulation, male-fertility enhancement, and anti-inflammatory actions. They also participate indirectly in the mechanism of wound healing as oxidative stress reducers. Glutathione peroxidase (GPX) is the major selenoprotein present in the human body, which assists in the control of excessive production of free radical at the site of inflammation. Other than GPX, other selenoproteins include selenoprotein-S that regulates the inflammatory cytokines and selenoprotein-P that serves as an inducer of homeostasis. Previously, reports were mainly focused on the cellular and molecular mechanism of wound healing with reference to various animal models and cell lines. In this review, the role of selenium and its possible routes in translational decoding of selenocysteine, synthesis of selenoproteins, systemic action of selenoproteins and their indirect assimilation in the process of wound healing are explained in detail. Some of the selenium containing compounds which can acts as cancer preventive and therapeutics are also discussed. These compounds directly or indirectly exhibit antioxidant properties which can sustain the intracellular redox status and these activities protect the healthy cells from reactive oxygen species induced oxidative damage. Although the review covers the importance of selenium/selenoproteins in wound healing process, still some unresolved mystery persists which may be resolved in near future.

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Section: Inorganic Selenium Compoundsmentioning

confidence: 98%

Selenium and selenoproteins: it’s role in regulation of inflammation

2020

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“…Among the Se compounds, SeNPs, as the emerging form of Se species, have attracted considerable attention. Judging from the current positive results of SeNPs against a range of cancers, SeNPs will play more critical roles in cancer prevention and therapy in the near future, especially in the era of precision medicine, where patients are provided with personalized and tailored treatment based on individual conditions and needs [75]. To conclude, in order to fully determine the potential of Se compounds, in particular the SeNPs, in cancer prevention and therapy, extensive further studies are required to better understand the underlying mechanisms behind the biophysiological effects of Se.…”

Section: Discussionmentioning

confidence: 99%

“…Selenite is the most studied form of inorganic Se compounds as it exhibits excellent chemopreventive and anticancer features [74]. Selenite could effectively inhibit cell proliferation of various types of cancer cells, including lung cancer, which is the most common and deadliest cancer worldwide [75]. Among different human cancer cell lines tested, lung cancer cells, in general, appeared to be especially sensitive to selenite [76,77,78,79].…”

Section: Se-containing Compounds and Their Usage In Oncologymentioning

confidence: 99%

“…Epigenetic refers to the study of heritable changes in gene expression that do not involve changes to the underlying DNA sequence [1,75]. These changes are controlled by epigenetic factors such as epimodifications of DNA, post-translational modification (PTM) of histone, and expression of non-coding RNA (ncRNA) [1].…”

Section: Se and Epigenetics: Possible Roles In Cancer Prevention Amentioning

confidence: 99%

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Selenium Species: Current Status and Potentials in Cancer Prevention and Therapy

Tan

Lau

et al. 2018

IJMS

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162

129

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Selenium (Se) acts as an essential trace element in the human body due to its unique biological functions, particularly in the oxidation-reduction system. Although several clinical trials indicated no significant benefit of Se in preventing cancer, researchers reported that some Se species exhibit superior anticancer properties. Therefore, a reassessment of the status of Se and Se compounds is necessary in order to provide clearer insights into the potentiality of Se in cancer prevention and therapy. In this review, we organize relevant forms of Se species based on the three main categories of Se—inorganic, organic, and Se-containing nanoparticles (SeNPs)—and overview their potential functions and applications in oncology. Here, we specifically focus on the SeNPs as they have tremendous potential in oncology and other fields. In general, to make better use of Se compounds in cancer prevention and therapy, extensive further study is still required to understand the underlying mechanisms of the Se compounds.

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“…Cd is associated with many human diseases and has adverse health effects even at low concentrations [1]. It is also a well-known carcinogen where it shows a particularly strong correlation with lung cancer, one of the most common and deadliest cancers worldwide [2,3]. Although the exact mechanisms of Cd carcinogenesis remain elusive, researchers have unveiled that Cd is likely to exert its deleterious effects on cells through multiple mechanisms, including induction of oxidative stress and inflammation, inhibition of apoptosis, aberration of gene expression, alteration of DNA methylation, and interference with DNA repair system [4,5].…”

Section: Introductionmentioning

confidence: 99%

Lasting DNA Damage and Aberrant DNA Repair Gene Expression Profile Are Associated with Post-Chronic Cadmium Exposure in Human Bronchial Epithelial Cells

Tan

Liang

Yao

et al. 2019

Cells

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Cadmium (Cd) is a widespread environmental pollutant and carcinogen. Although the exact mechanisms of Cd-induced carcinogenesis remain unclear, previous acute/chronic Cd exposure studies have shown that Cd exerts its cytotoxic and carcinogenic effects through multiple mechanisms, including interference with the DNA repair system. However, the effects of post-chronic Cd exposure remain unknown. Here, we establish a unique post-chronic Cd-exposed human lung cell model (the “CR0” cells) and investigate the effects of post-chronic Cd exposure on the DNA repair system. We found that the CR0 cells retained Cd-resistant property even though it was grown in Cd-free culture medium for over a year. The CR0 cells had lasting DNA damage due to reduced DNA repair capacity and an aberrant DNA repair gene expression profile. A total of 12 DNA repair genes associated with post-chronic Cd exposure were identified, and they could be potential biomarkers for identifying post-chronic Cd exposure. Clinical database analysis suggests that some of the DNA repair genes play a role in lung cancer patients with different smoking histories. Generally, CR0 cells were more sensitive to chemotherapeutic (cisplatin, gemcitabine, and vinorelbine tartrate) and DNA damaging (H2O2) agents, which may represent a double-edged sword for cancer prevention and treatment. Overall, we demonstrated for the first time that the effects of post-chronic Cd exposure on human lung cells are long-lasting and different from that of acute and chronic exposures. Findings from our study unveiled a new perspective on Cd-induced carcinogenesis—the post-chronic exposure of Cd. This study encourages the field of post-exposure research which is crucial but has long been ignored.

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Recent insights into human bronchial proteomics – how are we progressing and what is next?

Cited by 13 publications

References 138 publications

Selenium and selenoproteins: it’s role in regulation of inflammation

Selenium and selenoproteins: it’s role in regulation of inflammation

Selenium Species: Current Status and Potentials in Cancer Prevention and Therapy

Lasting DNA Damage and Aberrant DNA Repair Gene Expression Profile Are Associated with Post-Chronic Cadmium Exposure in Human Bronchial Epithelial Cells

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