Recent insights into nanoformulation delivery systems of flavonoids against glioblastoma

Alshweiat, Areen; Jaber, Mai; Abuawad, Alaa; Athamneh, Tamara; Oqal, Muna

doi:10.1016/j.jddst.2023.105271

Cited by 3 publications

(4 citation statements)

References 224 publications

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“…They are abundant in fruits, vegetables, and medicinal herbs. Quercetin (found in apples, onions), epicatechin (abundant in green tea, cocoa), and hesperidin (citrus fruits) are prominent flavonoids with notable antioxidant effects [29,30]. -Alkaloids: e a diverse group of nitrogen-containing compounds with varying pharmacological activities.…”

Section: Key Medicinal Plant Compounds Known For Their Antioxidant Pr...mentioning

confidence: 99%

Impact of Heavy Metal Pollution in the Environment on the Metabolic Profile of Medicinal Plants and Their Therapeutic Potential

Asiminicesei,

Fertu,

Gavrilescu

2024

Plants

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The paper provides a comprehensive examination of heavy metal stress on medicinal plants, focusing on its impact on antioxidant capacity and biosynthetic pathways critical to their therapeutic potential. It explores the complex relationship between heavy metals and the physiological and biochemical responses of medicinal plants, highlighting how metal stress disrupts biosynthetic pathways, altering concentrations of secondary metabolites. This disruption may compromise the overall quality and efficacy of medicinal plants, requiring a holistic understanding of its cumulative impacts. Furthermore, the study discusses the potential of targeted genetic editing to enhance plant resilience against heavy metal stress by manipulating genes associated with antioxidant defenses. This approach represents a promising frontier in safeguarding medicinal plants in metal-contaminated environments. Additionally, the research investigates the role of phytohormone signaling in plant adaptive mechanisms to heavy metal stress, revealing its influence on biochemical and physiological responses, thereby adding complexity to plant adaptation. The study underscores the importance of innovative technologies and global cooperation in protecting medicinal plants’ therapeutic potential and highlights the need for mitigation strategies to address heavy metal contamination effectively.

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Section: Key Medicinal Plant Compounds Known For Their Antioxidant Pr...mentioning

confidence: 99%

Impact of Heavy Metal Pollution in the Environment on the Metabolic Profile of Medicinal Plants and Their Therapeutic Potential

Asiminicesei,

Fertu,

Gavrilescu

2024

Plants

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“…Currently, for their stability and safety, BA nanoparticles are one of the most promising approaches with the potential to be translated into clinical use to improve the management of glioblastoma [84,96]. Nanotechnology-based drug delivery systems have undergone extensive evolution and research in recent years, and we can find studies conducted with nanoparticles composed of gold, carbon, lipid, and hybrid nanoparticles, among several other compositions [41,81,93,97,98]. The most promising nanoparticles identified thus far are hybrid polymer nanoformulations with ligands targeting receptors present in glioma cells.…”

Section: Delivery Strategies For Betulinic Acid Applicationmentioning

confidence: 99%

“…The most promising nanoparticles identified thus far are hybrid polymer nanoformulations with ligands targeting receptors present in glioma cells. These formulations exhibit biochemical versatility by combining various properties of different nanomaterials in a single nanoformulation [93,97].…”

Section: Delivery Strategies For Betulinic Acid Applicationmentioning

confidence: 99%

“…Those studies have often stalled at the animal model testing stage and the main causes are the current lack of evidence concerning the safety of these drugs, potential mid-to long-term toxicity, immunogenicity, and pharmacokinetic and pharmacodynamic profiles. Moreover, the diversity of nanoconstructs used, varying in size, shape, surface charge, and components, renders these nanomaterials highly variable which impacts negatively the standardization of the studies [41,81,93,97].…”

Section: Delivery Strategies For Betulinic Acid Applicationmentioning

confidence: 99%

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Betulinic Acid for Glioblastoma Treatment: Reality, Challenges and Perspectives

Fernandes,

Vieira,

Prudêncio

et al. 2024

IJMS

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Betulinic acid is a naturally occurring compound that can be obtained through methanolic or ethanolic extraction from plant sources, as well as through chemical synthesis or microbial biotransformation. Betulinic acid has been investigated for its potential therapeutic properties, and exhibits anti-inflammatory, antiviral, antimalarial, and antioxidant activities. Notably, its ability to cross the blood–brain barrier addresses a significant challenge in treating neurological pathologies. This review aims to compile information about the impact of betulinic acid as an antitumor agent, particularly in the context of glioblastoma. Importantly, betulinic acid demonstrates selective antitumor activity against glioblastoma cells by inhibiting proliferation and inducing apoptosis, consistent with observations in other cancer types. Compelling evidence published highlights the acid’s therapeutic action in suppressing the Akt/NFκB-p65 signaling cascade and enhancing the cytotoxic effects of the chemotherapeutic agent temozolomide. Interesting findings with betulinic acid also suggest a focus on researching the reduction of glioblastoma’s invasiveness and aggressiveness profile. This involves modulation of extracellular matrix components, remodeling of the cytoskeleton, and secretion of proteolytic proteins. Drawing from a comprehensive review, we conclude that betulinic acid formulations as nanoparticles and/or ionic liquids are promising drug delivery approaches with the potential for translation into clinical applications for the treatment and management of glioblastoma.

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Multifunctional carbonized polymer dots: Synthesis and applications in retarding protein amyloid aggregation, capturing free radicals and cell imaging

Li,

Wang,

Dong

et al. 2025

Journal of Molecular Structure

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Recent insights into nanoformulation delivery systems of flavonoids against glioblastoma

Cited by 3 publications

References 224 publications

Impact of Heavy Metal Pollution in the Environment on the Metabolic Profile of Medicinal Plants and Their Therapeutic Potential

Impact of Heavy Metal Pollution in the Environment on the Metabolic Profile of Medicinal Plants and Their Therapeutic Potential

Betulinic Acid for Glioblastoma Treatment: Reality, Challenges and Perspectives

Multifunctional carbonized polymer dots: Synthesis and applications in retarding protein amyloid aggregation, capturing free radicals and cell imaging

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