Recent Insights Into the Molecular Mechanism of Toll-Like Receptor Response to Dengue Virus Infection

Kayesh, Mohammad Enamul Hoque; Kohara, Michinori; Tsukiyama-Kohara, Kyoko

doi:10.3389/fmicb.2021.744233

Cited by 11 publications

(6 citation statements)

References 159 publications

(189 reference statements)

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“…In addition, when dengue patients recover from infection with one serotype, they can develop solid immunity against that particular serotype, but they are not able to avoid infection by other serotypes. These heterotypic infections may lead to the development of severe dengue as well as increased mortality [ 41 , 62 , 63 , 64 , 65 ]. Therefore, a continuous virological surveillance is critical for early warning of new serotype emergence in the circulation as well as for public health preparedness [ 66 ].…”

Section: Epidemiology Of Denv Infection and Correlation Of Serotypes ...mentioning

confidence: 99%

Increasing Dengue Burden and Severe Dengue Risk in Bangladesh: An Overview

Kayesh

Khalil²,

Kohara

et al. 2023

TropicalMed

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Dengue is a prevalent and rapidly spreading mosquito-borne viral disease affecting humans. The geographic range of dengue is expanding, and much like in many other tropical regions of the world, dengue has become a major public health issue in Bangladesh. Until a large epidemic dengue outbreak in 2000, sporadic outbreaks have occurred in Bangladesh since 1964. After 2000, varying intensities of dengue activity were observed each year until 2018. However, in 2019, Bangladesh experienced the largest dengue epidemic in its history, with 101,354 dengue cases and 164 dengue-related deaths. Notably, this outbreak occurred in many regions that were previously considered free of the disease. As of 10 December 2022, a total of 60,078 dengue cases and 266 dengue-related deaths were reported in Bangladesh, with the 2022 outbreak being the second largest since 2000. There is an increased genetic diversity of the dengue virus (DENV) in Bangladesh and all four DENV serotypes are prevalent and co-circulating, which increases the risk for severe dengue owing to the antibody-dependent enhancement effect. Vector control remains the mainstay of dengue outbreak prevention; however, the vector control programs adopted in Bangladesh seem inadequate, requiring improved vector control strategies. In this review, we provide an overview of the epidemiology of DENV infection and the risks for a severe dengue outbreak in Bangladesh. Additionally, we discuss different dengue vector control strategies, from which the most suitable and effective measures can be applied in the context of Bangladesh for tackling future dengue epidemics.

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Section: Epidemiology Of Denv Infection and Correlation Of Serotypes ...mentioning

confidence: 99%

Increasing Dengue Burden and Severe Dengue Risk in Bangladesh: An Overview

Kayesh

Khalil²,

Kohara

et al. 2023

TropicalMed

Self Cite

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“…Non-structural viral proteins were also demonstrated to activate TLRs. Non-structural protein 1 (NS1) of dengue virus activated TLR4 ( 142 ) while both NS3 and capsid proteins of hepatitis C virus activated TLR2, inducing pro-inflammatory cytokine release ( 143 ). NLRP3 inflammasome activation in macrophages by hepatitis C capsid protein was also demonstrated ( 144 ), suggesting that the same viral protein can mediate several cell signaling cascades.…”

Section: Discussionmentioning

confidence: 99%

Activation of NLRP3 Inflammasome by Virus-Like Particles of Human Polyomaviruses in Macrophages

et al. 2022

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Viral antigens can activate phagocytes, inducing inflammation, but the mechanisms are barely explored. The aim of this study is to investigate how viral oligomeric proteins of different structures induce inflammatory response in macrophages. Human THP-1 cell line was used to prepare macrophages that were treated with filamentous nucleocapsid-like particles (NLPs) of paramyxoviruses and spherical virus-like particles (VLPs) of human polyomaviruses. The effects of viral proteins on cell viability, pro-inflammatory cytokines’ production, and NLRP3 inflammasome activation were investigated. Filamentous NLPs did not induce inflammation while spherical VLPs mediated inflammatory response followed by NLRP3 inflammasome activation. Inhibitors of cathepsins and K+ efflux decreased IL-1β release and cell death, indicating a complex inflammasome activation process. A similar activation pattern was observed in primary human macrophages. Single-cell RNAseq analysis of THP-1 cells revealed several cell activation states different in inflammation-related genes. This study provides new insights into the interaction of viral proteins with immune cells and suggests that structural properties of oligomeric proteins may define cell activation pathways.

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“…The recognition of the DENV involves activation of both the MyD88 and IRF-3 or IRF-5 pathways, dependent on the specific viral components engaged in the interaction with the host’s immune response ( 135 ). Specifically, DENV2 triggers TLR3, TLR7, and TLR8, resulting in a robust induction of IL-8 and IFN-α ( 136 , 137 ).…”

Section: Tlrsmentioning

confidence: 99%

Sex-related immunity: could Toll-like receptors be the answer in acute inflammatory response?

Popotas,

Casimir,

Corazza

et al. 2024

Front. Immunol.

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An increasing number of studies have highlighted the existence of a sex-specific immune response, wherein men experience a worse prognosis in cases of acute inflammatory diseases. Initially, this sex-dependent inflammatory response was attributed to the influence of sex hormones. However, a growing body of evidence has shifted the focus toward the influence of chromosomes rather than sex hormones in shaping these inflammatory sex disparities. Notably, certain pattern recognition receptors, such as Toll-like receptors (TLRs), and their associated immune pathways have been implicated in driving the sex-specific immune response. These receptors are encoded by genes located on the X chromosome. TLRs are pivotal components of the innate immune system, playing crucial roles in responding to infectious diseases, including bacterial and viral pathogens, as well as trauma-related conditions. Importantly, the TLR-mediated inflammatory responses, as indicated by the production of specific proteins and cytokines, exhibit discernible sex-dependent patterns. In this review, we delve into the subject of sex bias in TLR activation and explore its clinical implications relatively to both the X chromosome and the hormonal environment. The overarching objective is to enhance our understanding of the fundamental mechanisms underlying these sex differences.

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Recent Insights Into the Molecular Mechanism of Toll-Like Receptor Response to Dengue Virus Infection

Cited by 11 publications

References 159 publications

Increasing Dengue Burden and Severe Dengue Risk in Bangladesh: An Overview

Increasing Dengue Burden and Severe Dengue Risk in Bangladesh: An Overview

Activation of NLRP3 Inflammasome by Virus-Like Particles of Human Polyomaviruses in Macrophages

Sex-related immunity: could Toll-like receptors be the answer in acute inflammatory response?

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