Recent Insights into the Neurobiology of Impulsivity

Mitchell, Marci R.; Potenza, Marc N.

doi:10.1007/s40429-014-0037-4

Cited by 58 publications

(45 citation statements)

References 169 publications

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“…Regarding the four constructs of impulsivity, urgency (e.g., relating to the tendency of responding to negative emotions irrationally resulting in problematic outcomes) has been associated with excessive recruitment of lateral prefrontal cortex (PFC) activity resulting in self‐regulatory failure (e.g., substance misuse) . Lack of premeditation has been associated with decreased gray matter volumes in the insula and putamen and postulated to relate to the efficacy of decision‐making processes . Lack of perseverance or lack of conscientiousness is linked to impaired anterior cingulate cortex (ACC) function, and the left ventrolateral and left anterior prefrontal cortices, relating to risky behaviors .…”

Section: Neurobiologymentioning

confidence: 99%

The neurobiology of impulsivity and substance use disorders: implications for treatment

Kozak

Lucatch

Lowe

et al. 2018

Annals of the New York Academy of Sciences

163

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Impulsivity is strongly associated with substance use disorders (SUDs). Our review discusses impulsivity as an underlying vulnerability marker for SUDs, and treatment of co‐occurring impulsivity in SUDs. Three factors should be considered for the complex relationship between impulsivity and a SUD: (1) the trait effect of impulsivity, centering on decreased cognitive and response inhibition, (2) the state effect resulting from either acute or chronic substance use on brain structure and function, and (3) the genetic and environmental factors (e.g., age and sex) may influence impulsive behavior associated with SUDs. Both subjective and objective measures are used to assess impulsivity. Together, treatment developments (pharmacological, behavioral, and neurophysiological) should consider these clinically relevant dimensions assessed by a variety of measures, which have implications for treatment matching in individuals with SUD. Despite its heterogeneity, impulsivity is a marker associated with SUDs and may be understood as an imbalance of bottom‐up and top‐down neural systems. Further investigation of these relationships may lead to more effective SUD treatments.

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Section: Neurobiologymentioning

confidence: 99%

The neurobiology of impulsivity and substance use disorders: implications for treatment

Kozak

Lucatch

Lowe

et al. 2018

Annals of the New York Academy of Sciences

163

View full text Add to dashboard Cite

show abstract

“…ADHD is characterized by elevated and persistent levels of inattention, locomotor activity, and impulsivity (American Psychiatric Association, 2013). The construct of impulsivity encompasses a wide range of phenomena (Evenden, 1999; Winstanley et al, 2006; Mitchell and Potenza, 2014; Sharma et al, 2013). The variety of impulsivity that characterizes ADHD is often described as a deficit in “behavioral inhibition” (Barkley, 1997; Wodka et al, 2007; Evenden, 1999) and “response inhibition capacity” (RIC; Chambers, Garavan, & Bellgrove, 2009).…”

Section: Introductionmentioning

confidence: 99%

Validation of a method to assess ADHD-related impulsivity in animal models

Watterson

Mazur

Sanabria

2015

Journal of Neuroscience Methods

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“…This result is according with the studies even if does not clarify the mechanism of this association [79][80][81][82]. Further studies could investigate the brain connection and the alteration of the regulation system.…”

Section: Substance Use Disorder: Sudmentioning

confidence: 47%

Obesity and Psychiatric Disorders in a Sample of Obese Candidates for Bariatric Surgery in Campania Region

Micanti¹,

Pecoraro²,

Mosca³

et al. 2017

Primary Health Care

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Introduction: Obesity is now considered as pandemic. 40% of Italian population is overweight or obese. Many studies emphasize the association of obesity with mental disorders specifically depressive and anxiety disorders, substance use disorder, personality disorder. It has to be distinguished from the mental dimensions: impulsivity, mood, anxiety and body image connected to the emotional regulation system producing eating behaviors. Obesity subjects differ in eating behaviors: gorging, snacking, sweeteating, grazing and binge that are characterised by different level of psychopathology. Mental disorders are also associated to eating behaviors. Bariatric surgery is considered gold standard therapy for obesity. However, follow-up studies underline that the association obesity-mental disorders determines weight loss failure.Methods: 2205 obese subjects underwent psychiatric assessment before bariatric surgery. Patients were divided into two groups as result of psychiatric assessment: 1392 obese subjects without association with mental disorders and 813 with mental disorders. These last (mean age 37,63 SD ± 12,07; 181 M, 632 W; mean body mass index (BMI), 45,16 SD ± 12,14) were enrolled in this study. Every patient underwent psychiatric evaluation. The absence of mental disorders was considered an exclusion criteria.

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Recent Insights into the Neurobiology of Impulsivity

Cited by 58 publications

References 169 publications

The neurobiology of impulsivity and substance use disorders: implications for treatment

The neurobiology of impulsivity and substance use disorders: implications for treatment

Validation of a method to assess ADHD-related impulsivity in animal models

Obesity and Psychiatric Disorders in a Sample of Obese Candidates for Bariatric Surgery in Campania Region

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