Recent insights into vitamin D, adipocyte, and adipose tissue biology

Bennour, Imene; Haroun, Nicole; Sicard, Flavie; Mounien, Lourdes; Landrier, Jean‐François

doi:10.1111/obr.13453

Cited by 22 publications

(20 citation statements)

References 153 publications

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“…Nevertheless, under high fat diet, we observed a rise in adiposity and insulin resistance in males, but not in females. Such Cells 2022, 11, 2024 2 of 14 observation strongly, together with others [12][13][14][15], supports an impact of VDD on adipose tissue physiology in perinatal context [16].…”

Section: Introductionsupporting

confidence: 54%

“…Of note, the relationship between vitamin D and adipose tissue physiology has been already demonstrated in adulthood, where VD anti-inflammatory effects in adipocyte and adipose tissue have been demonstrated in the context of obesity [16,17]. Indeed, obesity is classically associated with a low-grade inflammatory status in adipose tissue, resulting notably from the activation of several inflammatory signaling pathways including NF-B and p38/mapk [18].…”

Section: Introductionmentioning

confidence: 99%

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Maternal Vitamin D Deficiency in Mice Increases White Adipose Tissue Inflammation in Offspring

Haroun

Bennour

Seipelt

et al. 2022

Cells

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Vitamin D is acknowledged to play an important biological and metabolic role in adipose tissue, which is also the main storage site for this vitamin. Its anti-inflammatory effect in adipocytes and adipose tissue has notably been highlighted in adult mice. This vitamin is also crucial during fetal development since maternal vitamin D deficiency is suspected to program future metabolic disorders. Based on these observations, the aim of this study was to evaluate the consequences of maternal vitamin D deficiency (VDD) on white adipose tissue inflammation in adult offspring fed with normal or obesogenic diet (high-fat diet). White adipose tissue morphology, RNA and miRNA expression profiles, and signaling pathways were studied in adult males and females. In males, a HF diet coupled with maternal VDD increased expression of RNA and miRNA linked to inflammation leading to over-representation of inflammatory pathways. Interestingly, genomic and epigenetic profiles were associated with activation of the NF-kB signaling pathway and adiposity index. In females, no major modulation of inflammatory pathways was observed under VDD, contrarily to males. We concluded that maternal VDD coupled with HF diet activated inflammatory pathway in adipose tissue of the offspring, in a sex-dependent manner. Such activation is strongly related to activation of NF-kB signaling and increased adiposity only in males.

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Section: Introductionsupporting

confidence: 54%

Section: Introductionmentioning

confidence: 99%

Maternal Vitamin D Deficiency in Mice Increases White Adipose Tissue Inflammation in Offspring

Haroun

Bennour

Seipelt

et al. 2022

Cells

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“…These data support a longitudinal study that demonstrated 25(OH)D deficiency among patients who exhibited weight regain five-years post-RYGB, confirming that similar results are seen across these two different surgery types [ 11 ]. A possible mechanism of action for the impact of 25(OH)D on weight regain is the potential involvement of 25(OH)D in the suppression of genes involved in preadipocyte differentiation [ 24 , 42 , 43 ]. Higher 25(OH)D stores could therefore reduce the rate of adipogenesis and hence prevent weight gain.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D Levels as an Important Predictor for Type 2 Diabetes Mellitus and Weight Regain Post-Sleeve Gastrectomy

et al. 2022

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Weight Loss Surgery (WLS), including sleeve-gastrectomy (SG), results in significant weight loss and improved metabolic health in severe obesity (BMI ≥ 35 kg/m2). Previous studies suggest post-operative health benefits are impacted by nutrient deficiencies, such as Vitamin D (25(OH)D) deficiency, while it is currently unknown whether nutrient levels may actually predict post-surgery outcomes. As such, this study investigated whether 25(OH)D levels could predict metabolic improvements in patients who underwent SG. Patients with severe obesity (n = 309; 75% female) undergoing SG participated in this ethics-approved, non-randomized retrospective cohort study. Anthropometry, clinical data, 25(OH)D levels and serum markers were collected at baseline, 6-, 12- and 18-months post-surgery. SG surgery resulted in significant improvements in metabolic health at 6- and 12-months post-surgery compared with baseline, as expected. Patients with higher baseline 25(OH)D had significantly lower HbA1c levels post-surgery (p < 0.01) and better post-surgical T2DM outcomes, including reduced weight regain (p < 0.05). Further analysis revealed that baseline 25(OH)D could predict HbA1c levels, weight regain and T2DM remission one-year post-surgery, accounting for 7.5% of HbA1c divergence (p < 0.01). These data highlight that higher circulating 25(OH)D levels are associated with significant metabolic health improvements post-surgery, notably, that such baseline levels are able to predict those who attain T2DM remission. This highlights the importance of 25(OH)D as a predictive biomarker of post-surgery benefits.

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“…However, the mechanism of VD uptake and release in adipose tissue is still unclear, but evidence demonstrates that many mechanisms, including the megalin/cubilin pathway, cholesterol (TC) transporters, and other mechanisms, are involved in 25(OH)D uptake. In addition, lipolysis may be involved in VD release, and this process is reported to be blunted in obese individuals, suggesting that the adipose is a pool of VD and that the release of poor VD from adipose tissue may cause lower serum VD levels in obese people [ 35 ]. This suggests that obesity is a contributing factor to VD deficiency independent of insufficient VD intake and lack of sunshine.…”

Section: The Relationship Of Vd Deficiency During Pregnancy and Obesi...mentioning

confidence: 99%

“…Apart from classical target organ cells, such as the intestine, parathyroid gland, and bone, VDR is also widely present in tissues, such as the heart, skin, brain, pancreas, and immune system, and moderates certain biologic effects, including glucose and lipid metabolism, cell proliferation and differentiation, and the activation of immune cells. In obese individuals, VDR expression is elevated in adipose tissue compared with lean individuals [ 35 ]. Additionally, uncoupling protein-1 (UCP-1) is a member of the uncoupling protein family involved in thermogenesis, energy metabolism, and obesity.…”

Section: The Relationship Of Vd Deficiency During Pregnancy and Obesi...mentioning

confidence: 99%

The Role of Maternal Vitamin D Deficiency in Offspring Obesity: A Narrative Review

Zeng

Zhang

et al. 2023

Nutrients

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Currently, vitamin D (VD) deficiency during pregnancy is widespread globally, causing unfavorable pregnancy outcomes for both mothers and infants for a longer time than expected, based on the Developmental Origins of Health and Disease (DOHaD) theory. As VD plays a key role in maintaining normal glucose and lipid metabolism, maternal VD deficiency may lead to obesity and other obesity-related diseases among offspring later in life. This review mainly focuses on the effect of maternal VD deficiency on offspring lipid metabolism, reviewing previous clinical and animal studies to determine the effects of maternal VD deficit on offspring obesity and potential mechanisms involved in the progression of offspring obesity. Emerging clinical evidence shows that a low VD level may lead to abnormal growth (either growth restriction or largeness for gestational age) and lipid and glucose metabolism disorders in offspring. Here, we also outline the link between maternal VD deficiency and life-long offspring effects, including the disorder of adipogenesis, the secretion of adipocytokines (including leptin, resistin, and adiponectin), activated systemic inflammation, increased oxidative reactions in adipose tissue, insulin resistance, and abnormal intestinal gut microbiota. Thus, there is an urgent need to take active steps to address maternal VD deficiency to relieve the global burden of obesity.

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Recent insights into vitamin D, adipocyte, and adipose tissue biology

Cited by 22 publications

References 153 publications

Maternal Vitamin D Deficiency in Mice Increases White Adipose Tissue Inflammation in Offspring

Maternal Vitamin D Deficiency in Mice Increases White Adipose Tissue Inflammation in Offspring

Vitamin D Levels as an Important Predictor for Type 2 Diabetes Mellitus and Weight Regain Post-Sleeve Gastrectomy

The Role of Maternal Vitamin D Deficiency in Offspring Obesity: A Narrative Review

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