Recent isolates of parapoxvirus of Finnish reindeer (Rangifer tarandus tarandus) are closely related to bovine pseudocowpox virus

Tikkanen, Maria K.; McInnes, Colin J.; Mercer, Andrew A.; Büttner, Mathias; Tuimala, Jarno; Hirvelä-Koski, Varpu; Neuvonen, E.; Huovilainen, Anita

doi:10.1099/vir.0.79781-0

Cited by 73 publications

(54 citation statements)

References 21 publications

(14 reference statements)

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“…3 (data not shown). This confirms the proposition from previous studies of partial gene sequences that PCPV and ORFV are genetically more closely related to each other than either of them is to BPSV (Inoshima et al, 2001;Thomas et al, 2003;Tikkanen et al, 2004;Hosamani et al, 2006). This is despite BPSV and PCPV sharing the same bovine host, whereas the natural hosts of ORFV are sheep and goats.…”

Section: Comparison Of Predicted Ppv Protein Sequencessupporting

confidence: 80%

“…The aetiological agent has been identified as a parapoxvirus (PPV). It was demonstrated that two outbreaks of disease, one in 1992-1993 and one in 1999-2000, were apparently caused by different species of PPV (Tikkanen et al, 2004). The former, more severe outbreak with approximately 400 dead and about 2800 affected reindeer, was caused by a virus closely related to orf virus (ORFV), whereas the latter outbreak was caused by a virus showing notable partial sequence similarity to pseudocowpoxvirus (PCPV).…”

Section: Introductionmentioning

confidence: 99%

“…Previous analyses have established that PPVs form a distinct group on the phylogenetic tree of mammalian poxviruses (Thomas et al, 2003;Tikkanen et al, 2004;Delhon et al, 2004). The results of whole genome phylogenetic analyses and comparisons of the predicted protein sequences of F00.120R and VR634 with three (150) *The per cent amino acid identity with corresponding F00.120R ORF.…”

Section: Comparison Of Predicted Ppv Protein Sequencesmentioning

confidence: 99%

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The genome of pseudocowpoxvirus: comparison of a reindeer isolate and a reference strain

Hautaniemi

Ueda

Tuimala

et al. 2010

Journal of General Virology

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Parapoxviruses (PPV), of the family Poxviridae, cause a pustular cutaneous disease in sheep and goats (orf virus, ORFV) and cattle (pseudocowpoxvirus, PCPV and bovine papular stomatitis virus, BPSV). Here, we present the first genomic sequence of a reference strain of PCPV (VR634) along with the genomic sequence of a PPV (F00.120R) isolated in Finland from reindeer (Rangifer tarandus tarandus). The F00.120R and VR634 genomes are 135 and 145 kb in length and contain 131 and 134 putative genes, respectively, with their genome organization being similar to that of other PPVs. The predicted proteins of F00.120R and VR634 have an average amino acid sequence identity of over 95 %, whereas they share only 88 and 73 % amino acid identity with the ORFV and BPSV proteomes, respectively. The most notable differences were found near the genome termini. F00.120R lacks six and VR634 lacks three genes seen near the right terminus of other PPVs. Four genes at the left end of F00.120R and one in the middle of both genomes appear to be fragmented paralogues of other genes within the genome. VR634 has larger than expected inverted terminal repeats possibly as a result of genomic rearrangements. The high G+C content (64 %) of these two viruses along with amino acid sequence comparisons and whole genome phylogenetic analyses confirm the classification of PCPV as a separate species within the genus Parapoxvirus and verify that the virus responsible for an outbreak of contagious stomatitis in reindeer over the winter of 1999-2000 can be classified as PCPV.

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Section: Comparison Of Predicted Ppv Protein Sequencessupporting

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Section: Comparison Of Predicted Ppv Protein Sequencesmentioning

confidence: 99%

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The genome of pseudocowpoxvirus: comparison of a reindeer isolate and a reference strain

Hautaniemi

Ueda

Tuimala

et al. 2010

Journal of General Virology

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“…Some ORFVs were isolated from cases of bovine papular stomatitis in cattle and some BPSVs were isolated from sheep 15 . Moreover, both ORFV and BPSV cause pustular dermatitis in Japanese serows (Capricornis crispus) 6,7 and both ORFV and PCPV also cause papular stomatitis in Finnish reindeer (Rangifer tarandus tarandus) 19 . In addition, experimental transmission of parapoxvirus from the Japanese serow to sheep, goats and cattle has succeeded 11,13,14 .…”

Section: Introductionmentioning

confidence: 99%

Isolation and Characterization of a Parapoxvirus from Sheep with Papular Stomatitis

Kanou

Inoshima

Shibahara

et al. 2005

JARQ

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An outbreak of papular stomatitis occurred in a sheep herd in Hokkaido, Japan. Histological examination, immunohistochemistry, electron microscopic observation, and polymerase chain reaction (PCR) were carried out. Lesions were characterized by epithelial hyperplasia, acanthosis, ballooning degeneration of the spiny layer and stratum granulosum. A parapoxvirus was isolated from the skin lesion of affected sheep and characterized genetically and antigenically. Restriction endonuclease analysis of the PCR product showed an orf virus (ORFV)-specific pattern and the isolate reacted with monoclonal antibodies against ORFV. The partially deduced amino acid sequence of the viral envelope gene was identical to those of the major Japanese ORFVs. These results indicated that the outbreak was due to infection by parapoxvirus. The isolated virus could be classified into ORFV, and was closely related to the major Japanese ORFVs, but not foreign ORFVs or other parapoxviruses.

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“…Epidemics have occurred in these areas since December 1984, and 155 of 402 serows (39.6%) captured from December 1984 to March 1985 were clinically affected [40]. Tikkanen et al reported that a recent outbreak of PPV infection in Finnish reindeer (Rangifer tarandus tarandus; 1999 to 2000) was caused by pseudocowpox virus, a species of the genus Parapoxvirus, whereas an earlier outbreak (1992 to 1994) was caused by orf virus (ORFV), a prototype species of PPV [42]. Sequence analyses of the viral envelope gene indicate that contagious pustular dermatitis in Japanese serows is mainly caused by ORFV [18,19].…”

mentioning

confidence: 99%

Spatial and Temporal Genetic Homogeneity of Orf Viruses Infecting Japanese Serows (Capricornis crispus)

Inoshima

Ito

Ishiguro

2010

The Journal of Veterinary Medical Science

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ABSTRACT. This study genetically characterized orf viruses (ORFVs) isolated from recent outbreaks in Japanese serows (Capricornis crispus) in 2007 and 2008, and from earlier outbreaks from 1985 to 2001. Nucleotide sequences of genes for the viral envelope, vascular endothelial growth factor (VEGF), and virus interferon resistance (VIR) were determined in two ORFVs isolated from recent outbreaks and in eight from earlier outbreaks. No deletions or insertions were observed in these genes. Surprisingly, the amino acid sequences of the envelope and VIR genes were identical among the 10 ORFVs, and only one amino acid substitution in the VEGF gene was found in one of the two recent ORFVs (2007). Genotyping by differential PCR for the A32L gene, which encodes an ATPase, classified all of the 10 ORFVs into the same genotype. In an ORFV isolated from a sheep in 1970, the three sequenced genes were almost the same as in the ORFVs isolated from Japanese serows, and the ORFV in 1970 was classified into the same genotype as the ORFVs from Japanese serows. These results suggest that recent outbreaks in Japanese serows are caused by ORFVs genetically closely related to the viruses in earlier outbreaks and that these genetically stable ORFVs have circulated among Japanese serows over a long period of time.

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Recent isolates of parapoxvirus of Finnish reindeer (Rangifer tarandus tarandus) are closely related to bovine pseudocowpox virus

Abstract: Short CommunicationRecent isolates of parapoxvirus of Finnish reindeer (Rangifer tarandus tarandus) are closely related to bovine pseudocowpox virus

Cited by 73 publications

References 21 publications

The genome of pseudocowpoxvirus: comparison of a reindeer isolate and a reference strain

The genome of pseudocowpoxvirus: comparison of a reindeer isolate and a reference strain

Isolation and Characterization of a Parapoxvirus from Sheep with Papular Stomatitis

Spatial and Temporal Genetic Homogeneity of Orf Viruses Infecting Japanese Serows (Capricornis crispus)

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