Recent Literature Review on Coumarin Hybrids as Potential Anticancer Agents

Abstract

Cancer is considered as one of the leading causes of death in the world, especially patients with lung, pancreatic, or brain tumors are most likely to die of cancer and patients with prostate and breast cancer are at high risk of non-cancer death. As a result, there is on-going research regarding the development of new, safe and efficient anticancer agents. Coumarin-based naturally occurring compounds possess a broad spectrum of activity in medicinal chemistry such as anticancer, anti-inflammatory, antimicrobial, antioxidant agents, etc. Many researchers have synthesized coumarin-based novel therapeutic agents via molecular hybridization technique, which offers an excellent opportunity for development of novel compounds with improved biological activities by incorporating two or more pharmacophores. This review sheds light on the recent developments on coumarin based anticancer hybrid derivatives and their structure-activity relationships (SAR). This review serves as a medium that medicinal chemists could utilise for the design and synthesis of coumarin derivatives with significant pharmacological value as future anticancer agents.

Coumarin Derivatives: The Influence of Cycloalkyl Groups at the C-3 Position on Intermolecular Interactions—Synthesis, Structure and Spectroscopy

“…The recent literature on the therapeutic effects of coumarins reveals a range of potential medical applications for these compounds. The studies included the investigation of the pharmacological and biological impacts of coumarins, encompassing anti-inflammatory, anticoagulant, antihypertensive, anticonvulsant, antioxidant, antimicrobial, and neuroprotective activities [1][2][3][4][5][6][7][8]. This diverse range of activities makes coumarins promising candidates for the development of new therapeutic agents.…”

Design, synthesis, molecular docking study and molecular dynamics simulation of new coumarin-pyrimidine hybrid compounds having anticancer and antidiabetic activity

“…Coumarin rings are present in many bioactive compounds, which are widely found in nature as well as in biologically active new synthetic compounds [ 9 ]. These heterocyclic compounds exhibit a range of important pharmacological and biological activities, such as antidiabetic [ 10 ], anticancer [ 11 ], antifungal [ 12 ], and antibacterial [ 13 ] activity. Many derivatives containing coumarin ring display multifunctional bioactivity [ 6 ].…”