Recent nanotheranostics applications for cancer therapy and diagnosis: A review

Abstract

Nanotheranostics has attracted much attention due to its widespread application in molecular imaging and cancer therapy. Molecular imaging using nanoparticles has attracted special attention in the diagnosis of cancer at early stages. With the progress made in nanotheranostics, studying drug release, accumulation in the target tissue, biodistribution, and treatment effectiveness are other important factors. However, according to the studies conducted in this regard, each nanoparticle has some advantages and limitations that should be examined and then used in clinical applications. The main goal of this review is to explore the recent advancements in nanotheranostics for cancer therapy and diagnosis. Then, it is attempted to present recent studies on nanotheranostics used as a contrast agent in various imaging modalities and a platform for cancer therapy.This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Recent Metal Nanotheranostics for Cancer Diagnosis and Therapy: A Review

“…Iron-based NPs that include inorganic paramagnetic iron oxide (or magnetite) nanoparticles or superparamagnetic iron oxide nanoparticles (SPIONs) have been investigated as theranostic magnetic nanoparticles and are ideal agents for theranostic applications, especially cancer treatment due to their excellent properties, such as facile synthesis, biocompatibility, and biodegradability [1]. Iron NPs are useful as excellent MRI agents, photothermal therapy (PTT), photodynamic therapy (PDT), magnetic hyperthermia, radiation therapy, and chemo/biotherapeutics presented in varied investigations [64].…”

“…Nanoparticles in medicine have applications in developing novel therapeutic and diagnostic modalities for cancer treatment and detection [1]. In recent years, there has been growing interest in using nanoparticles in medicine, especially in medical imaging as a contrast agent, in radiation therapy as carriers for drug and gene delivery, and as a radio-sensitizer [2][3][4].…”

Low-dimensional nanomaterials as an emerging platform for cancer diagnosis and therapy

“…In recent years, LDNs have emerged and attracted intense attention due to their exclusive physical and chemical properties, such as their small size, high durability, chemical stability, biocompatibility, non-toxicity, environmental friendliness, and the ease of chemical functionalization and surface modification. LDN-based nano-imaging-guided theranostic nanoplatforms have opened new frontiers in cancer precision medicine, integrated imaging and therapy into multimodal theranostic nanoplatforms to achieve individualized diagnostic accuracy and therapy for patients ( Aminolroayaei et al, 2021 ; Huang et al, 2023 ). However, transforming academic research into clinical practice is still a challenging and currently unresolved problem in anti-cancer clinical practice therapies.…”

Current status of Cancer Nanotheranostics: Emerging strategies for cancer management

“…This issue can be conveniently bypassed when the chemotherapeutic drugs are given in a tumor-targeted manner. For such tumor targeting, nanoparticles offer an important ability to make sure that no off targeted drug delivery takes place and transports the therapeutic agents to particular tumor sites only [65]. Various nanocarriers can be conjugated with chemotherapeutic agents such as paclitaxel, doxorubicin, gemcitabine, carboplatin, etc.…”