2003
DOI: 10.1097/00002030-200303070-00001
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Recent observations on HIV type-1 infection in the genital tract of men and women

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Cited by 212 publications
(190 citation statements)
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“…The higher susceptibility of women to sexually transmitted infections (STIs) including HIV has been attributed to the African patriarchal norms of men dominating family decision-making and biological vulnerability of women (Magadi, 2011;Ackerman & de Klerk, 2002;Coombs et al, 2003;Phyllis, 2013). Given the tempo of the HIV/AIDS epidemic in South Africa, understanding the extent social values influence the vulnerability of women to HIV infection in marital relationships carries some sense of urgency.…”
Section: Literature Reviewmentioning
confidence: 99%
“…The higher susceptibility of women to sexually transmitted infections (STIs) including HIV has been attributed to the African patriarchal norms of men dominating family decision-making and biological vulnerability of women (Magadi, 2011;Ackerman & de Klerk, 2002;Coombs et al, 2003;Phyllis, 2013). Given the tempo of the HIV/AIDS epidemic in South Africa, understanding the extent social values influence the vulnerability of women to HIV infection in marital relationships carries some sense of urgency.…”
Section: Literature Reviewmentioning
confidence: 99%
“…Virus replicating within the male genital tract could therefore develop distinct, compartment-specific characteristics in response to these local selective pressures (10,16,17,20,21,32,41,50,53). Although genetic differences between blood-and semen-derived HIV in an individual have been documented, a seminal signature sequence remains elusive (6,10). This failure to identify a signature sequence could be attributable to the fact that previous efforts mainly focused on proviral DNA sequences, which often represent archival viral genotypes rather than contemporary, actively replicating variants (4,44).…”
Section: Most Human Immunodeficiency Virus (Hiv) Transmissionmentioning
confidence: 99%
“…35,36 Sexual transmission of HIV has been closely linked to viral load in the blood of the infected host, [37][38][39][40][41] which probably serves as a surrogate, albeit imperfect, for HIV concentration in the genital tract. 42,43 In addition to lowering plasma viral load to nearly undetectable levels, ART can decrease viral load in genital secretions, 44,45 although patients having a detectable semen HIV load may have no detectable virus in their blood plasma, highlighting the residual risk of HIV-1 transmission during unprotected intercourse. 46 Observational studies and recent modeling work have triggered considerable interest and concerns regarding the use of ART in HIV-infected individuals to prevent secondary transmission.…”
Section: Introductionmentioning
confidence: 99%