Recent outcome of Graves’ disease patients with papillary thyroid cancer

Yano, Yukiko; Shibuya, H.; Kitagawa, Wataru; Nagahama, Mitsuji; Sugino, Kiminori; Ito, Kunihiko; Ito, Koichi

doi:10.1530/eje-07-0136

Cited by 85 publications

(82 citation statements)

References 15 publications

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“…These data support the hypothesis that immune responses may influence DTC progression (Gupta et al 2001, Yano et al 2007, Muzza et al 2010. In fact, pathologists have long recognized that some tumors are densely infiltrated by cells of both innate and adaptive arms of the immune system, thereby reflecting inflammatory conditions arising in non-neoplastic tissues.…”

Section: Introductionsupporting

confidence: 77%

“…Immune responses against differentiated thyroid carcinomas (DTCs) have long been demonstrated (Matsubayashi et al 1995, Modi et al 2003 and associations between inflammatory microenvironment and DTCs repeatedly reported (Yano et al 2007, Muzza et al 2010, evidenced by a mixture of lymphocytes and macrophages frequently found within and inside or surrounding primary thyroid tumors (Modi et al 2003, French et al 2010. These data support the hypothesis that immune responses may influence DTC progression (Gupta et al 2001, Yano et al 2007, Muzza et al 2010.…”

Section: Introductionmentioning

confidence: 56%

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The role of the inflammatory microenvironment in thyroid carcinogenesis

Cunha¹,

Marcello²,

Ward³

2013

Endocrine-Related Cancer

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Immune responses against thyroid carcinomas have long been demonstrated and associations between inflammatory microenvironment and thyroid carcinomas repeatedly reported. This scenario has prompted scientists throughout the world to unveil how the inflammatory microenvironment is established in thyroid tumors and what is its influence on the outcome of patients with thyroid carcinoma. Many studies have reported the role of evasion from the immune system in tumor progression and reinforced the weakness of the innate immune response toward thyroid cancer spread in advanced stages. Translational studies have provided evidence that an increased density of tumor-associated macrophages in poorly differentiated thyroid carcinoma (DTC) is associated with an aggressive phenotype at diagnosis and decreased cancer-related survival, whereas well-DTC microenvironment enriched with macrophages is correlated with improved disease-free survival. It is possible that these different results are related to different microenvironments. Several studies have provided evidence that patients whose tumors are not infiltrated by lymphocytes present a high recurrence rate, suggesting that the presence of lymphocytes in the tumor microenvironment may favor the prognosis of patients with thyroid carcinoma. However, the effect of lymphocytes and other immune cells on patient outcome seems to result from complex interactions between the tumor and immune system, and the molecular pattern of cytokines and chemokines helps to explain the involvement of the immune system in thyroid tumor progression. The inflammatory microenvironment may help to characterize aggressive tumors and to identify patients who would benefit from a more invasive approach, probably sparing the vast majority of patients with an indolent disease from unnecessary procedures.

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Section: Introductionsupporting

confidence: 77%

Section: Introductionmentioning

confidence: 56%

The role of the inflammatory microenvironment in thyroid carcinogenesis

Cunha¹,

Marcello²,

Ward³

2013

Endocrine-Related Cancer

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“…The outcome may suggest that small carcinomas in Graves' patients have the same prognosis as larger carcinomas in euthyroid patients. Yano et al compared the features of 154 cases of papillary thyroid cancers diagnosed in patients with Graves' disease to a euthyroid group with thyroid cancer [ 46 ] and did not fi nd signifi cant diff erences in multifocality, lymph node metastases, or distant metastases between the Graves' disease and the euthyroid group. Edmonds et al, in their study with 502 patients with thyroid cancer, reported similar mortality rates when comparing patients with Graves' disease and with multinodular goiter to that of euthyroid patients matched for age [ 45 ] .…”

Section: Aggressivenessmentioning

confidence: 99%

Thyroid Cancer in Patients with Hyperthyroidism

2012

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“…Although not all studies are in agreement, a meta-analysis of ten studies showed a 2.77-fold increased incidence of thyroid cancer in patients with antibody evidence of Hashimoto's thyroiditis, compared with control populations (Singh et al 1999). Similar to the controversy in Hashimoto's thyroiditis, there is an ongoing debate about the association between Graves' disease and thyroid cancer incidence, and aggressiveness (Filetti et al 1988, Hales et al 1992, Pellegriti et al 1998, Yano et al 2007. Because Hashimoto's is often associated with progression to hypothyroidism and thus elevated serum TSH concentration and because TSH receptor stimulation is crucial to the pathogenesis of Graves' disease, it is possible that humoral thyroid autoimmunity is linked to thyroid cancer through the TSH receptor.…”

Section: Autoimmune Thyroid Disease and Thyroid Cancermentioning

confidence: 99%

The association between serum TSH concentration and thyroid cancer

Boelaert

2009

Endocrine-Related Cancer

126

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There is mounting evidence that the serum concentration of TSH is an independent predictor for the diagnosis of thyroid malignancy in patients with nodular thyroid disease. Furthermore, preoperative serum TSH concentrations are higher in patients with more aggressive tumours, suggesting a potential role for TSH in the progression of differentiated thyroid cancer. Based on these observations, patients with higher serum TSH concentrations and borderline cytological results may require more aggressive investigation and treatment when compared with those with lower baseline TSH levels. The mechanisms underlying the finding of higher serum TSH in patients with thyroid cancer remain unexplained. In this issue of Endocrine-Related Cancer, Fiore et al. have analysed the relationship between serum TSH and diagnosis of papillary thyroid cancer in 10 178 patients with nodular thyroid disease who were investigated by fine-needle aspiration biopsy. They found significantly higher TSH concentrations in patients who were subsequently diagnosed with thyroid cancer compared with those with benign disease. In addition, they found that the development of autonomous thyroid function (TSH!0.4 mU/ml) was associated with a reduction in the risk of papillary thyroid carcinoma. In this commentary, the evidence regarding the association between serum TSH and thyroid cancer is discussed placing these new findings into context.

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Recent outcome of Graves’ disease patients with papillary thyroid cancer

Abstract: Objective: The objective was to evaluate the clinical behavior and

Cited by 85 publications

References 15 publications

The role of the inflammatory microenvironment in thyroid carcinogenesis

The role of the inflammatory microenvironment in thyroid carcinogenesis

Thyroid Cancer in Patients with Hyperthyroidism

The association between serum TSH concentration and thyroid cancer

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