Recent Overview of Potent Antioxidant Activity of Coordination Compounds

Abstract

During recent decades, the complexation of organic ligands toward several metal ions of s-p and d-block has been applied as a plan to enhance its antioxidant performance. Due to their wide range of beneficial impacts, coordination compounds are widely used in industries, specifically in the medicinal and pharmaceutical fields. The activity is generally improved by chelation consequently knowing that the characteristics of both ligands and metals can lead to the development of greatly active compounds. Chelation compounds are a substitute for using the traditional synthetic antioxidants, because metal chelates present benefits, including a variety in geometry, oxidation states, and coordination number, that assist and favor the redox methods associated with antioxidant action. As well as understanding the best studied anti-oxidative assets of these compounds, coordination compounds are involved in the free radical scavenging process and protecting human organisms from the opposing effects of these radicals. The antioxidant ability can be assessed by various interrelated systems. The methodological modification offers the most knowledge on the antioxidant property of metal chelates. Colorimetric techniques are the most used, though electron paramagnetic resonance (EPR) is an alternative for metallic compounds, since color does not affect the results. Information about systems, with their benefits, and restrictions, permits a dependable valuation of the antioxidant performance of coordination compounds, as well as assisting application in various states wherever antioxidant drugs are required, such as in food protection, appropriate good-packaged foods, dietary supplements, and others. Because of the new exhaustive analysis of organic ligands, it has become a separate field of research in chemistry. The present investigation will be respected for providing a foundation for the antioxidant properties of organic ligands, future tests on organic ligands, and building high-quality antioxidative compounds.

Design, preparation, physicochemical characterization, structural conformational, biological evaluation, and DNA interaction for some new benzimidazole complexes

“…Once the DPPH radical is condensed through an electron donor, these color variations toward yellow, the studied chelates have been studied in this analysis in association with the reference anti‐oxidant (Vit. C, positive control) (Figure 10 and Table S4), whereas the applied blank model is only (MeOH, negative control) 43 . The DPPH radicals have been absorbed at 517 nm.…”

“…UV–vis spectrophotometer was applied to identify the absorption at 515 nm. DPPH inhibition (%) has been evaluated for each tested sample 43 : …”

“…After that a serial dilution offering every time a various dose, as accordingly, the IC 50 has been recognized. All tests have been applied in triplicate 43 …”

Design, synthesize, physicochemical characterization, nonlinear optical properties structural elucidation, biomedical studies, and DNA interaction of some new mixed ligand complexes incorporating 4,6‐dimethylpyrimidine derivative and imidazole ligand

“…A 0 represents the absorbance at t = 0 for blank control, in addition to A t represents the absorbance at t = 30 min for the resulting solution. Once a serial dilution presenting each period a several dose, as well all assessments were estimated in triplicate 34–36 …”

Exploring the biomedical potential and DNA interaction of some new mixed complexes incorporating 2-guanidinobenzimidazole and imidazole ligands supporting by DFT and molecular docking approaches

“…Antioxidant evaluation DPPH radical scavenging performance study is a reference test applied in antioxidant test. The antioxidant performance of the studied BIG ligand and studied metal chelates has been attained through the DPPH component as previously reported [63,64]. The tested chelates have been dissolved in DMSO to make various concentrations (10: 100 µg/ml) that mixed systematically with MeOH and certified to cooperate through the dark on around 0.5 h. Ascorbic acid was applied as a reference for positive control.…”