Recent patents in allergy and immunology: New pyrazinones for the diagnosis of allergies to aminocephalosporins

Synthesis of skeletally diverse β-lactam haptens for the in vitro diagnosis of IgE-mediated drug allergy

“…4 Other study reports pyrazinone derivatives as novel antigenic determinants of a-aminocephalosporins showing a low percentage of positivity. 5 Indeed, to meet the challenge of the accumulated burden and increasing demand, allergy specialists need to be supported with innovative, evidence-based approaches for drug-allergy assessment and delabeling. In this respect, diversity-oriented synthesis (DOS) provides an appealing route to access compounds with structural complexity and diversity and incorporate chemical features common to natural products, such as sp 3 -hybridized carbon atoms and basic nitrogen atoms stereogenic elements, and novel skeletons.…”