A multi-indicator paleolimnological study of sediments from Lake Ķūži (central Latvia) was used to obtain a comprehensive record of environmental changes in the Holocene. Periodicity in the changes and the main drivers (lake basin development, catchment properties, climate, human activities) of the sedimentary record was studied. In order to comprehend the whole-lake sedimentation during the Holocene, a detailed multiindicator record from the central part of the lake was integrated with records of sediment mass accumulation rates from four cores from different parts of the lake and a GPR (ground-penetrating radar) survey of the lake basin. The observed changes in the sedimentation regime that took place during the early Holocene are strongly linked with variations in climatic conditions, but the catchment and lake basin also played an important role. In the middle Holocene the water level was stable and the lake was influenced by climate mediated through changes in the catchment vegetation. Around 5 000 cal. BP sedimentation pattern changed, and three of the four main drivers made a comparably strong impact on the sedimentary signal. Since 2 000 cal. BP multiple indicators point to a major disturbance clearly related to human activity, which conceals the impact of the natural drivers.