Recent Perspective of Lactobacillus in Reducing Oxidative Stress to Prevent Disease

Abstract

During oxidative stress, an important factor in the development of many diseases, cellular oxidative and antioxidant activities are imbalanced due to various internal and external factors such as inflammation or diet. The administration of probiotic Lactobacillus strains has been shown to confer a range of antibacterial, anti-inflammatory, antioxidant, and immunomodulatory effects in the host. This review focuses on the potential role of oxidative stress in inflammatory bowel diseases (IBD), cancer, and liver-related diseases in the context of preventive and therapeutic effects associated with Lactobacillus. This article reviews studies in cell lines and animal models as well as some clinical population reports that suggest that Lactobacillus could alleviate basic symptoms and related abnormal indicators of IBD, cancers, and liver damage, and covers evidence supporting a role for the Nrf2, NF-κB, and MAPK signaling pathways in the effects of Lactobacillus in alleviating inflammation, oxidative stress, aberrant cell proliferation, and apoptosis. This review also discusses the unmet needs and future directions in probiotic Lactobacillus research including more extensive mechanistic analyses and more clinical trials for Lactobacillus-based treatments.

Structural characteristics of gut microbiota in longevity from Changshou town, Hubei, China

“…In fact, the potential association between Lactobacillus and longevity and health was proposed over a century ago (Mackowiak 2013 ). Recent studies have not only reported the important roles of Lactobacillus in gut homeostasis, immune regulation, inflammation, oxidative stress, and nervous system regulation, but also confirmed its significant potential in extending lifespan (Grompone et al 2012 ; Kumaree et al 2023 ; Zhao et al 2023 ). However, the specific mechanisms of Lactobacillus in delaying aging and maintaining healthy aging are still unclear.…”

Supplementation of Lactobacillus plantarum ATCC14917 mitigates non-alcoholic fatty liver disease in high-fat-diet-fed rats

“…The results of this study were consistent with the above study ( Hassan et al, 2020 ), L. plantarum ATCC14917 can reverse the changes in the structure of the gut microbiota induced by the HFD, notably the major bacterial phylum. In recent years, many studies have shown that probiotics can regulate intestinal flora to prevent intestinal flora imbalance, improve intestinal barrier function, reduce oxidative stress and inflammation, and improve lipid metabolism and NAFLD ( Cao et al, 2022 ; Hu et al, 2022 ; Arellano-García et al, 2023 ; Shin et al, 2023 ; Wang et al, 2023 ; Zhao et al, 2023 ). In addition, there are several studies on the effects of different probiotics on improving NAFLD in clinical trials ( Arellano-García et al, 2022 ; Noormohammadi et al, 2023 ; Zhou et al, 2023 ).…”

Role of probiotics in managing various human diseases, from oral pathology to cancer and gastrointestinal diseases

“…These polysaccharides act by downregulating the expression of MAPK mRNA and upregulating PTEN (Asoudeh-Fard et al, 2017). Research on L. lactis strains has revealed their capacity to secrete IL-10 and INF-β, as well as express antioxidants that mitigate the generation of reactive oxygen species (ROS) and reduce colonic damage in animal models (Zhao et al, 2023).…”