Recent phytochemical and pharmacological advances in the genus Potentilla L. sensu lato – An update covering the period from 2009 to 2020

Augustynowicz, Daniel; Latté, Klaus Peter

doi:10.1016/j.jep.2020.113412

Cited by 24 publications

(15 citation statements)

References 176 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The genus Potentilla L (Rosaceae family) consists of approximately 700 species of annual and biennial plants and small shrubs. Extract from the underground parts of Potentilla erecta (L.) Raeusch (tormentil extract [TE]) has been used in traditional ethnomedicine for the treatment of diarrhea and mild inflammation of the oral mucosa because of its antioxidant and anti-inflammatory activity (Tomczyk and Latté, 2009;Melzig and Böttger, 2020;Augustynowicz et al, 2021). The pharmacological properties of tormentil have been discussed in several reviews and it's monographs are included in the Russian Pharmacopoeia (14th edition), State Pharmacopoeia of the Republic of Belarus, ESCOP, in the British Pharmacopoeia, or the European Pharmacopoeia (10th edition) (Shikov et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Multidirectional Effects of Tormentil Extract on Hemostasis in Experimental Diabetes

Marcińczyk

Golaszewska

Gromotowicz-Popławska

et al. 2021

Front. Pharmacol.

Self Cite

View full text Add to dashboard Cite

In our previous study, we showed that ellagitannin- and procyanidin-rich tormentil extract (TE) decreased experimental arterial thrombosis in normoglycemic rats through platelet inhibition. TE also slightly increased coagulation and attenuated fibrinolysis; however, these effects did not nullify the antithrombotic effect of TE. The present study aimed to assess whether TE exerts antithrombotic activity in streptozotocin (STZ)-induced diabetes, which is characterized by pre-existing increased coagulation and impaired fibrinolysis, in vivo and ex vivo thrombosis assays. TE (100, 200, or 400 mg/kg, p. o.) was administered for 14 days to STZ-induced diabetic rats and mice. TE at 100 mg/kg dose decreased the thrombus area in the mice model of laser-induced thrombosis through its potent antiplatelet effect. However, TE at 200 mg/kg dose increased thrombus weight in electrically induced arterial thrombosis in rats. The prothrombotic effect could be due to increased coagulation and attenuated fibrinolysis. TE at 400 mg/kg dose also improved vascular functions, which was mainly reflected as an increase in the arterial blood flow, bleeding time prolongation, and thickening of the arterial wall. However, TE at 400 mg/kg dose did not exert antithrombotic effect. Summarizing, the present results show that TE may exert multidirectional effects on hemostasis in STZ-induced diabetic rats and mice. TE inhibited platelet activity and improved endothelial functions, but it also showed unfavorable effects by increasing the activity of the coagulation system and by inhibiting fibrinolysis. These contrasting effects could be the reason for model-specific influence of TE on the thrombotic process in STZ-induced diabetes.

show abstract

Section: Introductionmentioning

confidence: 99%

Multidirectional Effects of Tormentil Extract on Hemostasis in Experimental Diabetes

Marcińczyk

Golaszewska

Gromotowicz-Popławska

et al. 2021

Front. Pharmacol.

Self Cite

View full text Add to dashboard Cite

show abstract

“…Although the antimicrobial mechanism of traditional Chinese medicine Madeng'ai in our study is still unclear, many studies have reported phenolic compounds of traditional Chinese medicine Potentilla species could be the critical factor in their antimicrobial effects [11,25]. It inspires us an idea about future work direction in exploring the antimicrobial mechanism of traditional Chinese medicine Madeng'ai, a variety of Potenllia freyniana Bornm that could be considered relative to phenolic compounds as well.…”

Section: Discussionmentioning

confidence: 78%

Antimicrobial Activity Study of Chinese Medicine Madeng’ai

Tang¹,

Zhao²,

Zhang³

et al. 2021

Preprint

View full text Add to dashboard Cite

Background Due to the overuse of antibiotics, many multidrug-resistant bacteria have emerged, which brings huge challenges to the clinical treatment of bacterial infections. New products for anti-infection are necessary. Methods Madeng’ai powder was added with Milli-Q water or LB culture and autoclaved to prepare medicine suspension at different concentration. Bacteria were cultured in LB with different concentration of Madeng’ai. and swab on LB agar plates to get minimal inhibitory concentration (MIC) of Madeng’ai. Mice back was cut to make wound and MRSA/PAE suspension was injected in the wound area. Then swab with Madeng’ai extracts. Bacteria growth of infected secretions was checked on LB agar, and Hematoxylin and eosin (H&E) staining was performed for Histological analysis of skin tissues infected with bacteria after Madeng’ai and PBS (control) treatment. Results Madeng’ai could widely inhibit E.faecalis, Pseudomonas aeruginosa (PAE), Klebsiella pneumoniae (K.pneumoniae) and Acinetobacter baumannii (A.baumannii) at concentration of 4.0 mg/ml. The mice model also showed that Madeng’ai had imposed restrictions on MRSA and PAE growth in vivo. Conclusion Here, we report that a new Chinese medicine Madeng’ai has antimicrobial activity functions in vitro and in vivo. These data briefly showed that Madeng’ai functioned on antimicrobial and provided a new consideration for an antibiosis product.

show abstract

“…Although there are a significant number of reports concerning the traditional uses of plant species, there is an urgent need to evaluate plant-derived medications true clinical outcomes, their interactions with prescription medications, and long-term safety in vitro, in vivo, and in clinical studies [3,4].Potentilla alba L. (Rosaceae) has a long tradition of therapeutic use in Europe, especially in the eastern part of the continent. Mainly, the rhizome of this plant have been used alone or as a part of a comprehensive therapy to treat thyroid gland disorders [5,6]. Despite the great potential that has been revealed in several clinical studies conducted in Ukraine and the availability of methods enabling solid dosage form production with the white cinquefoil extract that complies with Russian Pharmacopeia requirements [7], there has been no herbal drug approved by the European Union that contains P. alba.…”

mentioning

confidence: 99%

“…Potentilla alba L. (Rosaceae) has a long tradition of therapeutic use in Europe, especially in the eastern part of the continent. Mainly, the rhizome of this plant have been used alone or as a part of a comprehensive therapy to treat thyroid gland disorders [5,6]. Despite the great potential that has been revealed in several clinical studies conducted in Ukraine and the availability of methods enabling solid dosage form production with the white cinquefoil extract that complies with Russian Pharmacopeia requirements [7], there has been no herbal drug approved by the European Union that contains P. alba.…”

mentioning

confidence: 99%

New Perspectives for the Use of Potentilla alba Rhizomes to Treat Thyroid Gland Impairments

Augustynowicz

Latté³

2021

Planta Med

Self Cite

View full text Add to dashboard Cite

Potentilla alba is a valuable medicinal plant that has been highly praised even before its first appearance in herbal books; however, it has now been forgotten in Western Europe. Currently, this species is used in Eastern Europe as a remedy to treat dysentery and various thyroid gland dysfunctions. The present review summarizes the advances in the phytochemical, pharmacological, and toxicological research related to this plant species. Clinical trials that have been conducted to date support its traditional use for treating thyroid disorders, although its exact mechanism of action, bioavailability, and pharmacokinetics data are missing.

show abstract

Recent phytochemical and pharmacological advances in the genus Potentilla L. sensu lato – An update covering the period from 2009 to 2020

Cited by 24 publications

References 176 publications

Multidirectional Effects of Tormentil Extract on Hemostasis in Experimental Diabetes

Multidirectional Effects of Tormentil Extract on Hemostasis in Experimental Diabetes

Antimicrobial Activity Study of Chinese Medicine Madeng’ai

New Perspectives for the Use of Potentilla alba Rhizomes to Treat Thyroid Gland Impairments

Contact Info

Product

Resources

About