Recent progress and challenges of MOF-based nanocomposites in bioimaging, biosensing and biocarriers for drug delivery

Nguyen, Ngoan Thi Thao; Nguyen, Thuy Thi Thanh; Ge, Shengbo; Liew, Rock Keey; Nguyen, Duyen Thi Cam; Tran, Thuan Van

doi:10.1039/d3na01075a

Cited by 24 publications

(2 citation statements)

References 209 publications

(210 reference statements)

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“…Nowadays, to discover many analytes and diagnose many diseases, live cell imaging has emerged as an innovative technology. In the case of living organisms, to anticipate many biological processes, fluorescence imaging is a nonintrusive imaging technique. , Moreover, in the field of biomedical application, porous substances have drawn much attention due to their large tunable pore size, high surface area, and controllable chemical properties. There are numerous kinds of cell imaging techniques that are available but fluorescence imaging has proved to be more trustworthy due to its sensitivity toward live cells. , Till now, various kinds of luminescent materials like quantum dots, nanosheets, and metal nanoclusters have been used for cell imaging. − But nowadays, MOFs are used as unique probes in cell imaging due to their luminescence performance and quenching and turn-on properties .…”

Section: Introductionmentioning

confidence: 99%

“…There are numerous kinds of cell imaging techniques that are available but fluorescence imaging has proved to be more trustworthy due to its sensitivity toward live cells. , Till now, various kinds of luminescent materials like quantum dots, nanosheets, and metal nanoclusters have been used for cell imaging. − But nowadays, MOFs are used as unique probes in cell imaging due to their luminescence performance and quenching and turn-on properties . Over the past few years, several research works on the bioimaging studies of MOF-based materials have been reported. ,− …”

Section: Introductionmentioning

confidence: 99%

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Two-Dimensional Cu-Based MOF for Selective Staining of the Cellular Nucleus through Fluorescence Imaging and Selective Sorption of Dye Molecules in Aqueous Medium

Hui,

Saha,

Guha

et al. 2024

Inorg. Chem.

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A two-dimensional copper-based metal–organic framework, [Cu(C23H14O6)(C10H8N2)2]·H2O·DMSO, 1, was synthesized using pamoic acid (C23H16O6) and 4,4′-bipyridine (C10H8N2) as an organic ligand and Cu(II) as a metal ion. Single-crystal structure X-ray diffraction studies of the as-synthesized compound showed a two- dimensional structure with free hydroxyl groups. Upon excitation at 370 nm, the aqueous dispersion of [Cu(C23H14O6)(C10H8N2)2]·H2O·DMSO, 1, showed emission centered at 525 nm resulting from the intraligand energy transfer. Fluorescence microscopic experiments using a human epithelioid cervix carcinoma HeLa cell line were carried out, clearly showing that our compound selectively stained the cellular nucleus. To utilize the porous nature of [Cu(C23H14O6)(C10H8N2)2]·H2O·DMSO, 1, its dye sorption behavior in aqueous solution was determined, and a high affinity for methylene blue (MB) dye was confirmed. Our synthesized compound sorbed 88% MB dye with an initial concentration of 32 mg L–1, and its sorption capacity for MB was found to be 29.79 mg g–1. The possible mechanism of the dye sorption behavior was discussed in terms of the size and charge of dye molecules with respect to molecular-level interactions between the framework and the dye molecules.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Two-Dimensional Cu-Based MOF for Selective Staining of the Cellular Nucleus through Fluorescence Imaging and Selective Sorption of Dye Molecules in Aqueous Medium

Hui,

Saha,

Guha

et al. 2024

Inorg. Chem.

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Iron‐MOFs for Biomedical Applications

Yu,

Lepoitevin,

Serre

2024

Adv Healthcare Materials

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Over the past two decades, iron‐based metal–organic frameworks (Fe‐MOFs) have attracted significant research interest in biomedicine due to their low toxicity, tunable degradability, substantial drug loading capacity, versatile structures, and multimodal functionalities. Despite their great potential, the transition of Fe‐MOFs–based composites from laboratory research to clinical products remains challenging. This review evaluates the key properties that distinguish Fe‐MOFs from other MOFs and highlights recent advances in synthesis routes, surface engineering, and shaping technologies. In particular, it focuses on their applications in biosensing, antimicrobial, and anticancer therapies. In addition, the review emphasizes the need to develop scalable, environmentally friendly, and cost‐effective production methods for additional Fe‐MOFs to meet the specific requirements of various biomedical applications. Despite the ability of Fe‐MOFs–based composites to combine therapies, significant hurdles still remain, including the need for a deeper understanding of their therapeutic mechanisms and potential risks of resistance and overdose. Systematically addressing these challenges could significantly enhance the prospects of Fe‐MOFs in biomedicine and potentially facilitate their integration into mainstream clinical practice.

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Nano‐ and Micro‐Platforms in Therapeutic Proteins Delivery for Cancer Therapy: Materials and Strategies

Han,

Santos

2024

Advanced Materials

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Proteins have emerged as promising therapeutics in oncology due to their great specificity. Many treatment strategies are developed based on protein biologics, such as immunotherapy, starvation therapy, and pro‐apoptosis therapy, while some protein biologics have entered the clinics. However, clinical translation is severely impeded by instability, short circulation time, poor transmembrane transportation, and immunogenicity. Micro‐ and nano‐particles‐based drug delivery platforms are designed to solve those problems and enhance protein therapeutic efficacy. This review first summarizes the different types of therapeutic proteins in clinical and research stages, highlighting their administration limitations. Next, various types of micro‐ and nano‐particles are described to demonstrate how they can overcome those limitations. The potential of micro‐ and nano‐particles are then explored to enhance the therapeutic efficacy of proteins by combinational therapies. Finally, the challenges and future directions of protein biologics carriers are discussed for optimized protein delivery.

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Recent progress and challenges of MOF-based nanocomposites in bioimaging, biosensing and biocarriers for drug delivery

Abstract: Here, we explored the recent development of MOF-based nanomaterials for biomedical applications. MOF-based nanomaterials not only show excellent bio-imaging and biosensing performance but also can be well designed as bio-carriers in drug delivery.

Cited by 24 publications

References 209 publications

Two-Dimensional Cu-Based MOF for Selective Staining of the Cellular Nucleus through Fluorescence Imaging and Selective Sorption of Dye Molecules in Aqueous Medium

Two-Dimensional Cu-Based MOF for Selective Staining of the Cellular Nucleus through Fluorescence Imaging and Selective Sorption of Dye Molecules in Aqueous Medium

Iron‐MOFs for Biomedical Applications

Nano‐ and Micro‐Platforms in Therapeutic Proteins Delivery for Cancer Therapy: Materials and Strategies

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