MXene, regarded as cutting‐edge two‐dimensional (2D) materials, have been widely explored in various applications due to their remarkable flexibility, high specific surface area, good mechanical strength, and interesting electrical conductivity. Recently, 2D MXene has served as a ideal platform for the design and development of electrocatalysts with high activity, selectivity, and stability. This review article provides a detailed description of the structural engineering of MXene‐based electrocatalysts and summarizes the uses of 2D MXene in hydrogen evolution reactions, nitrogen reduction reactions, oxygen evolution reactions, oxygen reduction reactions, and methanol/ethanol oxidation. Then, key issues and prospects for 2D MXene as a next‐generation platform in fundamental research and real‐world electrocatalysis applications are discussed. Emphasis will be given to material design and enhancement techniques. Finally, future research directions are suggested to improve the efficiency of MXene‐based electrocatalysts.