Recent Progress in Asymmetric Synthesis of Kabachnik-Fields Reaction

On the discovery and development of tandem 1,4- and 1,2-addition of phosphites to 1-azadienes

“…The best result was obtained with a minimal amount of CH 2 Cl 2 under reflux conditions (entry 14). However, the formed The reactions with pyridazine (entries [16][17][18][19][20] were performed with a minimal amount of solvent in analogy with the results obtained with pyrimidine under these reaction conditions. The best results were obtained under reflux conditions and sequential addition of P(OMe) 2 OTMS (entry 16).…”

Ultrasound-Promoted Kabachnik–Fields Synthesis of Novel Chromonyl α-Aminophosphonate Derivatives Incorporating Nitrogen Heterocycles Using CdI2 Nanoparticles as an Efficient Catalyst: Evaluation of Their Antifungal Properties

“…Synthesis of dialkyl α-aminophosphonates was cited in one-pot through three-component of aldehyde, amine and dialkyl phosphite (Kabachnik-Fields reaction). 25 Also, it is well-known that Schiff bases can react with dialkyl phosphite to give the same α-aminophosphonates (Pudovik reaction). 26 Both reaction types were performed in the presence or absence of a catalyst and solvent (Figure 2).…”

Chiral Brønsted Acid Catalyzed Enantioselective Phosphonylation of Allylamine via Oxidative Dehydrogenation Coupling

“…Because biological activity depends on their absolute configuration at the α-carbon atom, the development of an efficient way for the preparation of optically pure α-amino phosphonates is highly desired. The most straightforward strategy for the enantioselective synthesis of chiral α-amino phosphonates is the asymmetric addition of phosphites to imines (aza-Pudovik reaction). − Another widely used approach is the asymmetric Kabachnik–Fields reaction . For example, the List group developed a direct catalytic asymmetric Kabachnik–Fields reaction to furnish β-branched α-amino phosphonates using chiral phosphoric acid as catalyst .…”