Recent Progress in Barbituric Acid Chemistry

Bojarşki, Jacek; Mokrosz, Jerzy L.; Bartoń, H.; Paluchowska, Maria H.

doi:10.1016/s0065-2725(08)60921-6

Cited by 198 publications

(114 citation statements)

References 378 publications

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“…The IR data of the compounds 3a-g (Table 2) showed sharp as well as broad bands in the range (ν max ) 3463-3400 cm -1 indicating the presence of N-H group. The absorption bands at 1700-1650 cm -1 indicate the presence of non-conjugated C=O stretching including the barbituric acid moieties (Bojarski et al, 1985). The bands at…”

Section: Resultsmentioning

confidence: 99%

One step cyclocondensation of (thio) barbituric acid with chalcones in glacial acetic acid and phosphorous pentoxide, Part-II

Akhter

Halim

Ahmed

et al. 2017

Bangladesh J. Sci. Ind. Res.

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A number of new 5, 7-diaryl-1,5-dihydro (or 1, 2, 3, 5-tetrahydro)-pyrano [2, 3-d] pyrimidin-2, 4-diones (or 2-thioxo-4-ones) (3a-g) have been synthesized in one-step by cyclocondensation of barbituric acid or thiobarbituric acid (1) with arylideneacetophenones (2a-d), in glacial acetic acid in the presence of phosphorous pentoxide. The structures of the compounds 3a-g have been determined by UV, IR, 1H NMR, 13C NMR, mass spectral data and elemental analyses. The compounds 3a-g do not seem to be available in the literature.

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Section: Resultsmentioning

confidence: 99%

One step cyclocondensation of (thio) barbituric acid with chalcones in glacial acetic acid and phosphorous pentoxide, Part-II

Akhter

Halim

Ahmed

et al. 2017

Bangladesh J. Sci. Ind. Res.

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“…In the meanwhile, barbituric acid has been found to be associated with important biological activities including anti-hypertensive, anti-in ammatory, antitumor, anticonvulsant and hypnotic drugs [1][2][3][4][5][6][7][8][9][10][11][12]. We have succeeded to separate the active species which can act as nucleophile generated by aqueous diethylamine medium.…”

Section: Discussionmentioning

confidence: 99%

Crystal structure of diethylammonium 1,3-dimethyl-2,4,6-trioxohexahydropyrimidin-5-ide, C₁₀H₁₉N₃O₃

Barakat

Ghabbour

Al‐Majid

et al. 2016

Zeitschrift Für Kristallographie - New Crystal Structures

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“…Additionally, barbituric acid derivatives exhibit antifungal, antimicrobial, antiviral, potential mushroom tyrosinase inhibition, antituberculosos, radio-sensitization, anticancer with anti-in ammatory activities, inhibition for diaminopimelate aminotransferase, and anti-proliferative activity [1][2][3][4][5][6][7][8][9][10][11][12][13].…”

Section: Discussionmentioning

confidence: 99%

Crystal structure of 5-(3-fluorobenzylidene)-1,3-dimethylpyrimidine-2,4,6(1H,3H,5H)-trione; C₁₃H₁₁FN₂O₃

Barakat

Ghabbour

Al-Qahtani

et al. 2016

Zeitschrift Für Kristallographie - New Crystal Structures

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CCDC no.: 1452350The crystal structure is shown in the gure. Tables 1 and 2 contain details of the measurement method and a list of the atoms including atomic coordinates and displacement parameters. Source of materialA mixture of (1.0 mmol) 1,3-dimethylbarbituric acid and (1.0 mmol) 3-uorobenzaldehyde in 2.0 mL of H 2 O were charged into a 10 mL round bottom ask. The reaction mixture was stirred at room temperature for up to 30 min, until TLC showed complete consumption of both the reactants. After the completion of reaction, the solid product were collected by ltration and washed with 5 mL of water, and dried. 163.5, 162.2, 160.9, 160.2, 157.4, 151.2, 134.6, 129.8, 129.5, 119.8, 119.6, 119.4, 119.2, 29.2, 28.6. Experimental details"C-bound H atoms were placed in calculated positions and were included in the re nement in the riding model approximation. The H atoms of the methyl groups were allowed to rotate with a xed angle around the C-C bond to best t the experimental electron density" [7]. DiscussionBarbiturates show a wide range of pharmacological applications, such as general sedation, anesthesia,

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Recent Progress in Barbituric Acid Chemistry

Cited by 198 publications

References 378 publications

One step cyclocondensation of (thio) barbituric acid with chalcones in glacial acetic acid and phosphorous pentoxide, Part-II

One step cyclocondensation of (thio) barbituric acid with chalcones in glacial acetic acid and phosphorous pentoxide, Part-II

Crystal structure of diethylammonium 1,3-dimethyl-2,4,6-trioxohexahydropyrimidin-5-ide, C₁₀H₁₉N₃O₃

Crystal structure of 5-(3-fluorobenzylidene)-1,3-dimethylpyrimidine-2,4,6(1H,3H,5H)-trione; C₁₃H₁₁FN₂O₃

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Recent Progress in Barbituric Acid Chemistry

Cited by 198 publications

References 378 publications

One step cyclocondensation of (thio) barbituric acid with chalcones in glacial acetic acid and phosphorous pentoxide, Part-II

One step cyclocondensation of (thio) barbituric acid with chalcones in glacial acetic acid and phosphorous pentoxide, Part-II

Crystal structure of diethylammonium 1,3-dimethyl-2,4,6-trioxohexahydropyrimidin-5-ide, C10H19N3O3

Crystal structure of 5-(3-fluorobenzylidene)-1,3-dimethylpyrimidine-2,4,6(1H,3H,5H)-trione; C13H11FN2O3

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Crystal structure of diethylammonium 1,3-dimethyl-2,4,6-trioxohexahydropyrimidin-5-ide, C₁₀H₁₉N₃O₃

Crystal structure of 5-(3-fluorobenzylidene)-1,3-dimethylpyrimidine-2,4,6(1H,3H,5H)-trione; C₁₃H₁₁FN₂O₃