Recent progress in biological activities and health benefits of konjac glucomannan and its derivatives

Glucomannan as a Dietary Supplement for Treatment of Breast Cancer in a Mouse Model

“…Because of the anti-inflammatory and antitumor effect of glucomannan, we used this compound for the first time to treat breast cancer-bearing mice as an adjuvant in the tumor lysate cancer vaccine model and as a dietary supplement [ 19 , 46 ]. Furthermore, using an autologous tumor lysate as a vaccine antigen was considered reliable against tumor development because it might consist of all the essential epitopes that could boost CD4+ assistant T cells and CD8+ T cells [ 47 , 48 ].…”

High-protein high-konjac glucomannan diets changed glucose and lipid metabolism by modulating colonic microflora and bile acid profiles in healthy mouse models

“…The dietary protein and konjac glucomannan levels were referenced to previous studies to mimic the dietary protein and fiber intake of humans. 2,3,12,13,15 All diets were provided by Jiangsu Xietong Pharmaceutical Bio-engineering Co., Ltd (Nanjing, China). Each pair of mice was housed in one cage and marked with ear tags.…”

“…Konjac glucomannan is widely used as an alternative dietary supplement or functional food to prevent metabolic disorders, closely related to the role of the gut microbiota. 12,13 Additionally, recent research has highlighted that oligofructose supplementation modulated the gut microbiota, which mediated improvements in intestinal lipid sensing mechanisms that controlled food intake to regulate energy homeostasis in high-fat fed rats. 14 However, it should be noted that high fat and high sugar contents could mask the effects of dietary intervention when we interpret the effects of high DF and/or protein.…”

Diluted aqueous ionic liquid assists the acidic oxidative hydrolysis of water-soluble recalcitrant polysaccharide xanthan through structural deterioration

“…[3][4][5] Polysaccharide valorization produces mainly high-value chemicals, functional oligosaccharides, biofuels, polymers and composites. 2,3,[5][6][7][8][9] As one of the most consumed polysaccharides, xanthan gum (XG), and its modified derivatives, attract considerable industrial interest for applications in petroleum extraction, pharmaceutical formulation and food production, due to its favorable rheology properties, low price and renewability. 10 In addition to the selection of renewable polysaccharides for industrial production, the growing demand for sustainability and environmental protection is motivating the exploitation of gentle pretreatment methods, which could significantly reduce deleterious byproducts and energy consumption.…”

“…3–5 Polysaccharide valorization produces mainly high-value chemicals, functional oligosaccharides, biofuels, polymers and composites. 2,3,5–9 As one of the most consumed polysaccharides, xanthan gum (XG), and its modified derivatives, attract considerable industrial interest for applications in petroleum extraction, pharmaceutical formulation and food production, due to its favorable rheology properties, low price and renewability. 10…”