Recent progress in biosensor regeneration techniques

Jia, Yizhen; Chen, Shulin; Wang, Qi; Li, Jinghua

doi:10.1039/d3nr05456j

Nanoscale

2024

DOI: 10.1039/d3nr05456j

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Recent progress in biosensor regeneration techniques

Yizhen Jia,

Shulin Chen,

Qi Wang

et al.

Abstract: Biosensors are widely used in various applications, from medical diagnostics to environmental monitoring. Their widespread and continuous use necessitates regeneration methods to ensure cost-effectiveness and sustainability. In the realm of...

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Cited by 11 publications

References 37 publications

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Accurately Tunable AuNC‐ZIF Content Architecture Based on Coordination‐Dissociation Mechanism Enables Highly Brightness Dual‐Site Fluorescent Biosensor

Chen,

Wang,

Shen

et al. 2024

Advanced Science

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The quantum yield and fluorescence intensity of gold nanocluster (AuNC) nanocarriers are critical parameters for developing ultrasensitive biosensors. In this study, AuNCs‐zeolitic‐imidazolate‐framework (Au‐ZIF) nanocomposites are systematically constructed by impregnating AuNCs onto the ZIF‐8 surface through a coordination‐dissociation mechanism, resulting in a dual‐site fluorescence‐loaded structure. In this configuration, AuNCs are anchored to the external surface while the integrity of the inner cavity remains intact. The surface of ZIF‐8 induces a confinement effect on the configuration and electrons of AuNCs, significantly enhancing luminescence (18‐fold increase). The quantum yield of AuNCs exhibits an increase of more than 13‐fold, from 2.80% to 38.1%. This approach demonstrates broad applicability and maintains strong fluorescence across different ZIFs. Additionally, a novel nanocomposite, Au‐ZIF@carbon‐dots (CDs), is synthesized by encapsulating CDs into the inner cavity of Au‐ZIF. A ratiometric fluorescence detection platform is subsequently developed and incorporated into hydrogels for the quantitative detection of the pesticide triazophos. By employing an image‐processing algorithm, quantitative detection is achieved with a detection limit of 0.07 ng mL⁻1. The findings provide crucial insights into the relationship between the assembly and performance of AuNCs and ZIFs, offering guidance for designing ultrasensitive multifunctional biosensors applicable in the field of biosensing.

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Accurately Tunable AuNC‐ZIF Content Architecture Based on Coordination‐Dissociation Mechanism Enables Highly Brightness Dual‐Site Fluorescent Biosensor

Chen,

Wang,

Shen

et al. 2024

Advanced Science

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show abstract

Culture-free detection of β-lactamase-Producing bacteria in urinary tract infections using a paper sensor

Liu,

Li,

et al. 2024

Biosensors and Bioelectronics

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Integrating machine learning and biosensors in microfluidic devices: A review

Antonelli,

Filippi,

D’Orazio

et al. 2024

Biosensors and Bioelectronics

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Recent progress in biosensor regeneration techniques

Abstract: Biosensors are widely used in various applications, from medical diagnostics to environmental monitoring. Their widespread and continuous use necessitates regeneration methods to ensure cost-effectiveness and sustainability. In the realm of...

Cited by 11 publications

References 37 publications

Accurately Tunable AuNC‐ZIF Content Architecture Based on Coordination‐Dissociation Mechanism Enables Highly Brightness Dual‐Site Fluorescent Biosensor

Accurately Tunable AuNC‐ZIF Content Architecture Based on Coordination‐Dissociation Mechanism Enables Highly Brightness Dual‐Site Fluorescent Biosensor

Culture-free detection of β-lactamase-Producing bacteria in urinary tract infections using a paper sensor

Integrating machine learning and biosensors in microfluidic devices: A review

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