Recent progress in capillary electrophoretic analysis of amino acid enantiomers

Enantioresolution of Amino Acids: A Decade’s Perspective, Prospects and Challenges

“…In the CE analysis of AAs, the selection of separation mode is one of the most important issues to obtain good resolution of target enantiomers. Kitagawa et al [128] presented a comprehensive review on the progresses in CE analysis of AA enantiomers in the last decade. They discussed various chiral selectors including CDs, bile salts, crown ethers, cinchona alkaloids, metal-chiral AA complexes, macrocyclic antibiotics and proteins that have been employed to separate AA enantiomers.…”

“…In 2014, Miyoishi et al [128] used 2D-HPLC after pre-column derivatization with 4-fluoro-7-nitro-2,1,3-benzoxadiazole (NBD-F) for AA analysis, by fluorescence detection, in Kurozu vinegars. They found that Kurozu vinegars made by traditional earthenware jar fermentation contain large amounts of l-AAs.…”

Indirect Enantioseparation of Amino Acids by CE Using Automated In-Capillary Derivatization with ortho-Phthalaldehyde and N-Acetyl-l-Cysteine

“…Newer methods employ evaporative light scattering detector (ELSD) or charged aerosol detector (CAD) [9,10]. However, capillary electrophoresis has been proved to be worth especially when it comes to the separation of enantiomers [11]. It benefits Abstract A simple CE method for the assessment of enantiomeric purity of individual amino acids (AAs) is presented.…”

Enantiomeric discrimination of leucine enantiomers by nanotubular cyclic peptides: DFT and ONIOM calculation of the absorption spectra of guested enantiomers

“…In addition to the experimental works for chiral separation of amino acids and other chiral compounds, in recent years, with the development of computational chemistry, theoretical studies have been performed to predict potential ability of chiral separating agents to resolution of enantiomers [33][34][35][36][37][38][39][40][41]. For example, Lipkowitz in his review pointed to theoretical papers that used cyclodextrin for separation of chiral compounds [37].…”