Recent Progress in Drug Release Testing Methods of Biopolymeric Particulate System

Abstract

Biopolymeric microparticles have been widely used for long-term release formulations of short half-life chemicals or synthetic peptides. Characterization of the drug release from microparticles is important to ensure product quality and desired pharmacological effect. However, there is no official method for long-term release parenteral dosage forms. Much work has been done to develop methods for in vitro drug release testing, generally grouped into three major categories: sample and separate, dialysis membrane, and continuous flow (flow-through cell) methods. In vitro drug release testing also plays an important role in providing insight into the in vivo performance of a product. In vitro release test with in vivo relevance can reduce the cost of conducting in vivo studies and accelerate drug product development. Therefore, investigation of the in vitro–in vivo correlation (IVIVC) is increasingly becoming an essential part of particulate formulation development. This review summarizes the principles of the in vitro release testing methods of biopolymeric particulate system with the recent research articles and discusses their characteristics including IVIVC, accelerated release testing methods, and stability of encapsulated drugs.

Microfluidic Systems For Manufacturing of Microparticle-Based Drug-Delivery Systems: Design, Construction, and Operation

“…Step 4 is the particle characterization in regards to size, size distribution, and morphology of the particles, as well as drug encapsulation efficiency. Additionally, microparticles can be further characterized for in vitro release kinetics by already established quality-control protocols used in clinical applications to represent the in vitro – in vivo correlation. , …”

“…Additionally, microparticles can be further characterized for in vitro release kinetics by already established quality-control protocols used in clinical applications to represent the in vitro−in vivo correlation. 26,27 Procedure Overview. An overview of the procedure is detailed here:…”

Multipolymer microsphere delivery of SARS-CoV-2 antigens

“…Confirmation of cargo loading within particles is investigated by release in the case of drug payloads [ 58 , 59 ] for quantitative high-performance liquid chromatography or fluorophore-tagged payload for visualization by CLSM [ 60 , 61 ]. High resolution image Z-axis optical acquisition with dual-excitation and dual-emission mode was used to identify viral loading into the porous MS was carried out using a Nikon A1r CLSM ( Fig.…”

Nanopartiküler İlaç Taşıyıcı Sistemlerinin İncelenmesinde Kullanılan İn Vitro Salım Testi Yöntemlerine Genel Bir Bakış

“…USP aparatı 4, normalde USP'de modifiye salım sağlayan oral dozaj şekillerinin in vitro salım testi için geliştirilmiş olup akış hızı, hücre tiplerinin çeşitliliği ve salım ortamı hacminin esnek olması nedeniyle değişik dozaj şekilleri için de bu yöntem uygulanmaktadır [131,132]. Bu yöntemde, ilaç salımı, nanopartiküler sistemleri içeren hücreden geçerek sistemde sürekli sirküle edilen ortamda gerçekleşir ve elüent periyodik aralıklarla toplanarak analiz edilir [93].…”