Recent Progress in Electrochemical Aptasensors: Construction and Application

Yuan, Renqiang; Cai, Jing; Ma, Haojie; Luo, Yi; Wang, Lianhui; Su, Shao

doi:10.3390/chemosensors11090488

Cited by 11 publications

(3 citation statements)

References 135 publications

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“…82 Electrochemical aptasensors have significantly advanced fields such as disease diagnosis, drug safety, biochemical analysis, environmental monitoring, and public safety by virtue of their exceptional qualities: rapid response time, straightforward fabrication, uncomplicated configuration, heightened specificity for chemical and biological compounds, exceptional chemical stability, and economical price. 83 The electrochemical detection of the chratoxin A (OTA) toxin was carried out, with the OTA aptamer being utilised as illustrated in Fig. 3A.…”

Section: Innovations In Biosensing Technologiesmentioning

confidence: 99%

“…These microscopic structures have special qualities and high surface-to-volume ratios, making them ideal for raising detection limits. 83 Lab-on-a-chip devices enable accurate control of samples and reactions on a single microfluidic platform by automating and downsizing intricate analytical procedures. When combined, these advancements make it possible to create quick, accurate, and very sensitive biosensors that can be quickly and easily carried out for use in environmental monitoring, healthcare, and other fields.…”

Section: Future Directions and Emerging Trendsmentioning

confidence: 99%

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Review—Aptamers and Biomimetic Receptors in Biosensing: Innovations and Applications

Tripathi,

Pandey,

Mishra

et al. 2024

J. Electrochem. Soc.

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The fields of biosensing have been transformed by the discovery of extraordinary molecular recognition components, such as aptamers and biomimetic receptors. Systematic Evolution of Ligands by Exponential Enrichment (SELEX) is a method used to select aptamers, or short sequences of single-stranded DNA (ssDNA) or RNA (ssRNA), based on their unique binding affinity to target molecules. Molecularly imprinted polymers (MIPs) are a type of biomimetic receptor that mimics the selectivity of natural receptors inside a synthetic matrix. They make it possible to identify pathogens, and illness biomarkers with accuracy. Aptamers and biomimetic receptors play crucial roles in various fields including diagnostics, therapeutics, and biosensing. Their high specificity, versatility, and adaptability enable targeted detection, drug delivery, and biomolecule manipulation, thereby contributing to advancements in personalized medicine, biotechnology, and disease diagnosis. Aptamers and biomimetic receptors have been combined with cutting-edge technologies, like nanotechnology and lab-on-a-chip systems, to create biosensors that are quick, portable, and extremely sensitive. These recognition features are anticipated to become more important as technology develops, helping to address global issues, advance biosensing capabilities, and raise people's standard of living everywhere. Recent advancements and innovation on Aptamers and Biomimetic Receptors in Biosensing have been discussed in this review article.

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Section: Innovations In Biosensing Technologiesmentioning

confidence: 99%

Section: Future Directions and Emerging Trendsmentioning

confidence: 99%

Review—Aptamers and Biomimetic Receptors in Biosensing: Innovations and Applications

Tripathi,

Pandey,

Mishra

et al. 2024

J. Electrochem. Soc.

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“…Impedimetric biosensors are therefore applicable in a variety of fields, including medical diagnostics, environmental monitoring, and food safety [ 124 , 125 ]. They are particularly well suited for real-time monitoring and interaction involving larger biomolecules such as cells, proteins, and nucleic acids [ 113 , 126 ].…”

Section: Electrochemical Biosensing Platformsmentioning

confidence: 99%

Self-assembling biomolecules for biosensor applications

Kim,

Kang,

Kwon

et al. 2023

Biomater Res

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Molecular self-assembly has received considerable attention in biomedical fields as a simple and effective method for developing biomolecular nanostructures. Self-assembled nanostructures can exhibit high binding affinity and selectivity by displaying multiple ligands/receptors on their surface. In addition, the use of supramolecular structure change upon binding is an intriguing approach to generate binding signal. Therefore, many self-assembled nanostructure-based biosensors have been developed over the past decades, using various biomolecules (e.g., peptides, DNA, RNA, lipids) and their combinations with non-biological substances. In this review, we provide an overview of recent developments in the design and fabrication of self-assembling biomolecules for biosensing. Furthermore, we discuss representative electrochemical biosensing platforms which convert the biochemical reactions of those biomolecules into electrical signals (e.g., voltage, ampere, potential difference, impedance) to contribute to detect targets. This paper also highlights the successful outcomes of self-assembling biomolecules in biosensor applications and discusses the challenges that this promising technology needs to overcome for more widespread use. Graphical Abstract

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