Recent Progress in Elucidating the Structure, Function and Evolution of Disease Resistance Genes in Plants

Liu, Jinling; Liu, Xionglun; Dai, Liangying; Wang, Guo‐Liang

doi:10.1016/s1673-8527(07)60087-3

Cited by 182 publications

(134 citation statements)

References 80 publications

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“…Five functional CNL genes against different pathogens have been identified in Arabidopsis (Liu et al, 2007). According to the recovered evolutionary history of Arabidopsis CNL genes in Figure 7, RPM1 was the most ancient one among the five genes, possibly originating from the common ancestor of angiosperms, whereas the RPP8/HRT was most recent, possibly originating after Arabidopsis speciation.…”

Section: Deciphering the Evolution Of Arabidopsis Nbs Genesmentioning

confidence: 99%

“…Several functional NBS genes have been identified in angiosperm species (Liu et al, 2007); however, their time of emergence and relationship with other NBS genes have not been established. For example, several CNL genes have been identified in both soybean (Glycine max; Rpg1b and Rpg1r) and Arabidopsis (RPM1 and RPS2) against the bacterial pathogen Pseudomonas syringae by guarding the host protein RIN4 (Bent et al, 1994;Mackey et al, 2002;Mackey et al, 2003;Ashfield et al, 2014).…”

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confidence: 99%

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Large-Scale Analyses of Angiosperm Nucleotide-Binding Site-Leucine-Rich Repeat Genes Reveal Three Anciently Diverged Classes with Distinct Evolutionary Patterns

et al. 2016

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Nucleotide-binding site-leucine-rich repeat (NBS-LRR) genes make up the largest plant disease resistance gene family (R genes), with hundreds of copies occurring in individual angiosperm genomes. However, the expansion history of NBS-LRR genes during angiosperm evolution is largely unknown. By identifying more than 6,000 NBS-LRR genes in 22 representative angiosperms and reconstructing their phylogenies, we present a potential framework of NBS-LRR gene evolution in the angiosperm. Three anciently diverged NBS-LRR classes (TNLs, CNLs, and RNLs) were distinguished with unique exon-intron structures and DNA motif sequences. A total of seven ancient TNL, 14 CNL, and two RNL lineages were discovered in the ancestral angiosperm, from which all current NBS-LRR gene repertoires were evolved. A pattern of gradual expansion during the first 100 million years of evolution of the angiosperm clade was observed for CNLs. TNL numbers remained stable during this period but were eventually deleted in three divergent angiosperm lineages. We inferred that an intense expansion of both TNL and CNL genes started from the Cretaceous-Paleogene boundary. Because dramatic environmental changes and an explosion in fungal diversity occurred during this period, the observed expansions of R genes probably reflect convergent adaptive responses of various angiosperm families. An ancient whole-genome duplication event that occurred in an angiosperm ancestor resulted in two RNL lineages, which were conservatively evolved and acted as scaffold proteins for defense signal transduction. Overall, the reconstructed framework of angiosperm NBS-LRR gene evolution in this study may serve as a fundamental reference for better understanding angiosperm NBS-LRR genes.

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Section: Deciphering the Evolution Of Arabidopsis Nbs Genesmentioning

confidence: 99%

mentioning

confidence: 99%

Large-Scale Analyses of Angiosperm Nucleotide-Binding Site-Leucine-Rich Repeat Genes Reveal Three Anciently Diverged Classes with Distinct Evolutionary Patterns

et al. 2016

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“…The LRR domain is most frequently attributed the role of an intramolecular regulator that inhibits the receptor activity when an appropriate elicitor is absent. After binding a proper MIMP or MAMP, conformational changes within the LRR domain would take place leading to the dissociation of the LRR domain from the NBS domain and consequently, to the activation of the receptor [47,48]. Recent data showed that the dissociation of the LRR and NBS domains might not be required for the activation of the receptor [49,50].…”

Section: The Lrr Domainmentioning

confidence: 99%

R proteins as fundamentals of plant innate immunity

Głowacki

Macioszek

Kononowicz

2011

Cellular and Molecular Biology Letters

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Abstract:Plants are attacked by a wide spectrum of pathogens, being the targets of viruses, bacteria, fungi, protozoa, nematodes and insects. Over the course of their evolution, plants have developed numerous defense mechanisms including the chemical and physical barriers that are constitutive elements of plant cell responses locally and/or systemically. However, the modern approach in plant sciences focuses on the evolution and role of plant protein receptors corresponding to specific pathogen effectors. The recognition of an invader's molecules could be in most cases a prerequisite sine qua non for plant survival. Although the predicted three-dimensional structure of plant resistance proteins (R) is based on research on their animal homologs, advanced technologies in molecular biology and bioinformatics tools enable the investigation or prediction of interaction mechanisms for specific receptors with pathogen effectors. Most of the identified R proteins belong to the NBS-LRR family. The presence of other domains (including the TIR domain) apart from NBS and LRR is fundamental for the classification of R proteins into subclasses. Recently discovered additional domains (e.g. WRKY) of R proteins allowed the examination of their localization in plant cells and the role they play in signal transduction during the plant resistance response to biotic stress factors. This review focuses on the current state of knowledge about the NBS-LRR family of plant R proteins: their structure, function and evolution, and the role they play in plant innate immunity.

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“…(Rossman et al 1990), is one of the most serious diseases of cultivated rice (Oryza sativa L.) worldwide. Despite dozens of ''major'' disease-resistance (R) loci, which are known as Pi, being available (Zeigler et al 1994), only six, Pib, Pi-ta, Pi36, Pi9, Pi2, and Piz-t, have been cloned and characterized so far (Liu et al 2007). The Pi-ta gene commonly used in rice breeding worldwide originated from indica cultivars and was introgressed into japonica cultivars to control rice blast disease in the 1950s (Rybka et al 1997).…”

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confidence: 99%

Molecular Evolution of thePi-taGene Resistant to Rice Blast in Wild Rice (Oryza rufipogon)

et al. 2008

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Rice blast disease resistance to the fungal pathogen Magnaporthe grisea is triggered by a physical interaction between the protein products of the host R (resistance) gene, Pi-ta, and the pathogen Avr (avirulence) gene, AVR-pita. The genotype variation and resistant/susceptible phenotype at the Pi-ta locus of wild rice (Oryza rufipogon), the ancestor of cultivated rice (O. sativa), was surveyed in 36 locations worldwide to study the molecular evolution and functional adaptation of the Pi-ta gene. The low nucleotide polymorphism of the Pi-ta gene of O. rufipogon was similar to that of O. sativa, but greatly differed from what has been reported for other O. rufipogon genes. The haplotypes can be subdivided into two divergent haplogroups named H1 and H2. H1 is derived from H2, with nearly no variation and at a low frequency. H2 is common and is the ancestral form. The leucine-rich repeat (LRR) domain has a high p non /p syn ratio, and the low polymorphism of the Pi-ta gene might have primarily been caused by recurrent selective sweep and constraint by other putative physiological functions. Meanwhile, we provide data to show that the amino acid Ala-918 of H1 in the LRR domain has a close relationship with the resistant phenotype. H1 might have recently arisen during rice domestication and may be associated with the scenario of a blast pathogen-host shift from Italian millet to rice.

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Recent Progress in Elucidating the Structure, Function and Evolution of Disease Resistance Genes in Plants

Cited by 182 publications

References 80 publications

Large-Scale Analyses of Angiosperm Nucleotide-Binding Site-Leucine-Rich Repeat Genes Reveal Three Anciently Diverged Classes with Distinct Evolutionary Patterns

Large-Scale Analyses of Angiosperm Nucleotide-Binding Site-Leucine-Rich Repeat Genes Reveal Three Anciently Diverged Classes with Distinct Evolutionary Patterns

R proteins as fundamentals of plant innate immunity

Molecular Evolution of thePi-taGene Resistant to Rice Blast in Wild Rice (Oryza rufipogon)

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