Recent progress in enzymatic antioxidant defense system in plants against different environmental stresses

Mir, Rayees Ahmad; Khah, Mushtaq Ahmad

doi:10.1016/b978-0-443-18927-2.00014-5

Cited by 3 publications

(1 citation statement)

References 163 publications

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“…SOD catalyzes the dismutation of superoxide radicals (O 2 •−) into O 2 and hydrogen peroxide (H 2 O 2 ), by avoiding the accumulation of superoxide radicals. 147 The detoxification of the H 2 O 2 and its conversion into H 2 O and O 2 is performed by catalase and peroxidases which alleviate oxidative damage to cellular components. The activity and expression of EA are firmly regulated in response to exposure to Pb, along with TFs like AP2/ERF and NAC which contribute a crucial role in modulating antioxidant gene expression.…”

Section: Adaptive Mechanisms Of Plants To Pb Toxicitymentioning

confidence: 99%

Lead toxicity in plants: mechanistic insights into toxicity, physiological responses of plants and mitigation strategies

Gupta,

Dwivedi,

Kumar

et al. 2024

Plant Signaling & Behavior

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Section: Adaptive Mechanisms Of Plants To Pb Toxicitymentioning

confidence: 99%

Lead toxicity in plants: mechanistic insights into toxicity, physiological responses of plants and mitigation strategies

Gupta,

Dwivedi,

Kumar

et al. 2024

Plant Signaling & Behavior

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Antioxidant mechanisms in salt-stressed Maize (Zea mays L.) seedlings: comparative analysis of tolerant and susceptible genotypes

Methela,

Islam,

Das

et al. 2024

Appl Biol Chem

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Recent anthropogenic activities have spurred unparalleled environmental changes, among which elevated salinity levels emerge as a substantial threat to plant growth and development. This threat is characterized by oxidative stress, marked by the excessive generation of reactive oxygen species (ROS), proline accumulation, and lipid peroxidation. This study investigated the response of four maize (Zea mays L.) genotypes - two tolerant (9120 and Super Gold) and two susceptible (Pacific 984 and PS999) - to salinity-induced oxidative stress. Seedlings aged seven days were exposed to 12 dSm− 1 salinity stress for five days, with various parameters including relative water content (RWC), ROS accumulation, proline levels, lipid peroxidation, lipoxigenase (LOX) activity, enzymatic and non-enzymatic antioxidants, and glyoxalases evaluated in fully expanded leaves. Susceptible genotypes exhibited higher RWC loss compared to tolerant genotypes, while proline accumulation was elevated in the latter. Enhanced ROS production (hydrogen peroxide and superoxide), melondialdehyde (MDA) levels, and LOX activity were observed in susceptible genotypes under salinity stress, along with increased oxidation of glutathione (GSH) and ascorbate (ASA) compared to tolerant genotypes. Enzymatic antioxidants such as superoxide dismutase (SOD), peroxidase (POD), glutathione peroxidase (GPX), and monodehydroascorbate reductase (MDHAR) displayed higher activity in tolerant genotypes, while catalase (CAT) activity was significantly different between tolerant and susceptible genotypes under salinity stress in maize. Conversely, elevated activities of ascorbate peroxidase (APX), glutathione S-transferase (GST), glutathione reductase (GR), and dehydroascorbate reductase (DHAR) were observed in both genotypes, indicating their crucial role in cellular protection against ROS and metabolites during salt stress. In short, plants have devised tactics to scavenge surplus Reactive Oxygen Species (ROS) and uphold cellular redox balance amidst oxidative stress. This study aims to offer basic knowledge regarding both enzymatic and nonenzymatic antioxidants, and the defense mechanisms they constitute against ROS detoxification upon salt stress conditions; furthermore, it also explores their interactions with cellular components.

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Understanding the Impact of Oxidative Stress on Ovarian Cancer: Advances in Diagnosis and Treatment

Meshkovska,

Abramov,

Mahira

et al. 2024

Future Pharmacology

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Ovarian cancer (OC) ranks as the fifth most common cancer among women in the United States and globally, posing a significant health threat. Reactive oxygen species (ROS) have emerged as critical factors in the pathophysiology of this malignancy. ROS, characterized by their instability due to an unpaired electron, are involved in essential cellular functions and play a crucial role in the immune response under normal physiological conditions. However, an imbalance in ROS homeostasis, leading to excessive ROS production, results in oxidative stress (OS), which can cause indiscriminate damage to cellular structures and contribute to the pathogenesis of specific diseases, including OC. OC is primarily classified based on the originating cell type into epithelial, stromal, and germinal tumors, with epithelial tumors being the most prevalent. Despite advancements in medical technology, early detection of OC remains challenging, often leading to delayed treatment initiation. Current therapeutic approaches include surgical excision of tumor tissue, radiotherapy, and chemotherapy. While these treatments are effective in early-stage OC, high mortality rates and frequent relapse underscore the urgent need for novel diagnostic and therapeutic strategies. This review aims to elucidate the role of ROS in OC, emphasizing the potential for developing innovative diagnostic tools and treatments that target ROS-mediated pathways. Given the critical impact of early detection and effective treatment, advancing our understanding of ROS in the context of OC could significantly enhance patient outcomes.

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Recent progress in enzymatic antioxidant defense system in plants against different environmental stresses

Cited by 3 publications

References 163 publications

Lead toxicity in plants: mechanistic insights into toxicity, physiological responses of plants and mitigation strategies

Lead toxicity in plants: mechanistic insights into toxicity, physiological responses of plants and mitigation strategies

Antioxidant mechanisms in salt-stressed Maize (Zea mays L.) seedlings: comparative analysis of tolerant and susceptible genotypes

Understanding the Impact of Oxidative Stress on Ovarian Cancer: Advances in Diagnosis and Treatment

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