Recent Progress in Hyaluronic-Acid-Based Hydrogels for Bone Tissue Engineering

Abstract

Hydrogel-based bone tissue engineering is a potential strategy for treating bone abnormalities and fractures. Hyaluronic acid (HA) is a natural polymer that is widely distributed in the human body and plays a significant role in numerous physiological processes such as cell migration, tissue hydration, and wound healing. Hydrogels based on HA and its derivatives have gained popularity as potential treatments for bone-related diseases. HA-based hydrogels have been extensively studied for their ability to mimic the natural extracellular matrix of bone tissue and provide a suitable microenvironment for cell support and tissue regeneration. The physical and chemical properties of HA can be modified to improve its mechanical strength, biocompatibility, and osteogenic potential. Moreover, HA-based hydrogels combined with other biomaterials in the presence or absence of bioactive agents have been investigated as a means of improving the mechanical properties and bioactivity of the hydrogel scaffold. Therefore, HA-based hydrogels have shown great promise in bone tissue engineering due to their biocompatibility, osteogenic activity, and ability to mimic the natural extracellular matrix of bone tissue. Overall, this review provides a comprehensive overview of the current state of the art in HA-based hydrogels for bone tissue engineering, highlighting the key advances, challenges, and future directions in this rapidly evolving field.

Janus hydrogels: merging boundaries in tissue engineering for enhanced biomaterials and regenerative therapies

“…They also help deliver bioactive molecules and drugs to target sites that promote tissue regeneration. 109,110 However, simple hydrogels often have limited functionality beyond providing a structural scaffold for cell growth. Multifunctional hydrogels are advanced materials that have additional functions beyond the basic properties of simple hydrogels.…”

Nanotechnological Research for Regenerative Medicine: The Role of Hyaluronic Acid

“…In recent research on innovative tools to improve bone regeneration, HA has been used alone or combined with other biomaterials such as collagen, chitosan, silk fibroin, gelatin, and synthetic polymers [63]. Arjama et al [64] developed an injectable hydrogel based on functionalized composite of HA and hydroxyapatite, crosslinked with silk fibroin.…”

Hydrogel Microparticles for Bone Regeneration

“…The success of tissue engineering hinges on the harmonious interaction and integration of cells and tissues using suitable cellular and physical cues [7]. Injectable materials, such as hydrogels, have been explored extensively in recent years as an alternative to invasive surgical procedures [8][9][10][11].…”