Recent progress in integrated neglected tropical disease control

Hotez, Peter J.; Raff, Sophia; Fenwick, Alan; Richards, Frank O.; Molyneux, David

doi:10.1016/j.pt.2007.08.015

Cited by 95 publications

(73 citation statements)

References 22 publications

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“…Several sub-Saharan African countries have received support from United Nations (UN) and nongovernmental organizations (NGOs) to control schistosomiasis along with other NTDs (Hotez et al, 2007b). Nigeria, however, has only received limited international support due to absence of governmental commitment and reliable empirical data.…”

Section: Introductionmentioning

confidence: 99%

Mapping and prediction of schistosomiasis in Nigeria using compiled survey data and Bayesian geospatial modelling

et al. 2013

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Abstract. Schistosomiasis prevalence data for Nigeria were extracted from peer-reviewed journals and reports, geo-referenced and collated in a nationwide geographical information system database for the generation of point prevalence maps. This exercise revealed that the disease is endemic in 35 of the country's 36 states, including the federal capital territory of Abuja, and found in 462 unique locations out of 833 different survey locations. Schistosoma haematobium, the predominant species in Nigeria, was found in 368 locations (79.8%) covering 31 states, S. mansoni in 78 (16.7%) locations in 22 states and S. intercalatum in 17 (3.7%) locations in two states. S. haematobium and S. mansoni were found to be co-endemic in 22 states, while co-occurrence of all three species was only seen in one state (Rivers). The average prevalence for each species at each survey location varied between 0.5% and 100% for S. haematobium, 0.2% to 87% for S. mansoni and 1% to 10% for S. intercalatum. The estimated prevalence of S. haematobium, based on Bayesian geospatial predictive modelling with a set of bioclimatic variables, ranged from 0.2% to 75% with a mean prevalence of 23% for the country as a whole (95% confidence interval (CI): 22.8-23.1%). The model suggests that the mean temperature, annual precipitation and soil acidity significantly influence the spatial distribution. Prevalence estimates, adjusted for school-aged children in 2010, showed that the prevalence is <10% in most states with a few reaching as high as 50%. It was estimated that 11.3 million children require praziquantel annually (95% CI: 10.3-12.2 million).

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Section: Introductionmentioning

confidence: 99%

Mapping and prediction of schistosomiasis in Nigeria using compiled survey data and Bayesian geospatial modelling

et al. 2013

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“…Although there had been p rogress since the init iat ion of MDA Programmes, challenges have emerged. These include: the inability of some countries to sustain MDA, non-availability of data to indicate level and duration of treat ments to eliminate LF, and a shift towards linking MDA for LF control and other neglected diseases [6]. These challenges have led to gro wing concerns on the effect iveness of MDA alone to eliminate LF, without vector control as a co mplement [7].…”

Section: Introductionmentioning

confidence: 99%

Breeding Sites of <i>Culex quinquefasciatus</i> (Say) during the Rainy Season in Rural Lowland Rainforest, Rivers State, Nigeria

Okiwelu¹,

Noutcha²

2012

PHR

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Breeding sites of Culex quinquefasciatus (Say) were investigated during a World Bank Assisted Project on Integrated Vector Management (IVM ) for malaria control at 5 v illages (Ipo, Ozuaha, Oman wa, Omademe, Ub ima) in the Ikwerre Local Govern ment Area (LGA ). The study was in the rainy season, June-September, 2009, in ru ral lowland rainforest, Rivers State, Nigeria. Samp ling was undertaken daily in a randomly selected (100 m x 100 m) grid in each village. Nu mber of Cx. quinquefasciatus (Say) immatures was appro ximately 6-fold that of An. gambiae s.l. Nearly 80% of Cx. quinquefasciatus immatures were fro m container-type breeding sites (metal, p lastic containers, "calabashes", tyres) and least fro m phytotelmata. The differences were significant (F Cal =35695636; F Tab =39.86; d f 1, 1; p<0.01). Plastic containers were the preferred site-type in this category. The container-type breeding sites also yielded the highest number of immatures per breeding site. In the pools breeding site-types, approximately 55% were fro m puddles and 45% fro m gutters; the difference was not significant (F Cal =334975; F Tab =39.86; df 1,1; p >0.01). In the phytotelmata breeding site-types, about 67% of Cx. quinquefasciatus immatures were fro m depressions on trees; the difference in total numbers among site-types was significant (F Cal =2.47x10 8 ; F Tab =39.86; df 1,1; p<0.01). The container-type breeding sites yielded approximately 90% of immatures at Omanwa, but decreased to 60% at Omademe. In contrast, nearly 70% of immatures were fro m pools at Ozuaha and 80% fro m phytotelmata at Ub ima. These variat ions were significant (F Cal =4305.94; F Tab =39.86; df 1,1; p<0.01). The results indicate that Cx. quinquefasciatus had invaded rural areas and their breed ing sites ubiquitous and variable among villages, highlighting the needs for studies locally, prior to larviciding.

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“…2 The proliferation of health initiatives has also led to further fragmentation of the overall health effort, and there are increasing calls for integration within the primary health care system. 6,7 Greater integration is particularly relevant for the delivery of those community-level interventions in which the community itself participates. 6,8 There is little scientific evidence, however, on how to achieve this integration within the context of primary health care.…”

Section: Introductionmentioning

confidence: 99%

Community-directed interventions for priority health problems in Africa: results of a multicountry study

Group

2009

Bull. World Health Organ.

138

145

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Recent progress in integrated neglected tropical disease control

Cited by 95 publications

References 22 publications

Mapping and prediction of schistosomiasis in Nigeria using compiled survey data and Bayesian geospatial modelling

Mapping and prediction of schistosomiasis in Nigeria using compiled survey data and Bayesian geospatial modelling

Breeding Sites of <i>Culex quinquefasciatus</i> (Say) during the Rainy Season in Rural Lowland Rainforest, Rivers State, Nigeria

Community-directed interventions for priority health problems in Africa: results of a multicountry study

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