“…However, both of these are relatively expensive materials so they point towards the possibility to use a separate sterile microfluidic component, such as a capillary, to reduce the cost of disposal and replacement for each biological sample [30]. It is also possible to integrate piezoelectric materials in thick [53] or thin film [54,55] form, or indeed bonded bulk material [56], with other components. Requiring an additional level of fabrication sophistication, typically including photolithography [57], this approach may be very useful when the number of devices is high and may be a key issue in differentiating acoustic manipulation from optical manipulation [58], where integration is still much harder.…”