Recent progress in melt crystallization

Hong, Feng; Wang, Na; Huang, Xin; Wang, Ting; Zhou, Lanlan; Hao, Hongxun

doi:10.1016/j.cherd.2022.12.030

Cited by 14 publications

(3 citation statements)

References 42 publications

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“…However, these operations use a lot of energy, which remarkably raises the cost of the process. To meet market demand, the development of eco-friendly and effective crystallization purification technology and the renewal of crystallization machinery will raise increasing concerns, with the intention of decreasing energy consumption, shortening the crystallization cycle, and boosting crystallization efficiency during the production of citric acid and citrate [56][57][58][59].…”

Section: Main Methods For Citrate Crystallizationmentioning

confidence: 99%

Research Progress in the Industrial Crystallization of Citrate—A Review

Qin

Yan

et al. 2023

Crystals

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The citrate industry has a wide range of applications in food, pharmaceutical, and other fields. As a common class of food additives and functional supplements with tremendous development potential and strong core competitiveness, particles with good powder characteristics and functionalization are becoming one of the primary directions in the evolution of citrate into the high-end market. This article reviews the primary citrate crystallization techniques and examines the fundamental citrate crystallization mechanisms by describing citrate nucleation and growth during the industrial crystallization process. A variety of citrate hydrates are also summarized. The primary control conditions of the three essential product indices of purity, particle size, and grain shape are established. The need to take into account the density, fluidity, caking resistance, dissolution rate, suspension, bioavailability, and other indices of products is highlighted, along with applications for products that meet the purity and particle size requirements. While summarizing industrial citrate crystallization equipment, this paper also discusses the beneficial effect of continuous crystallization in achieving industrialization. Finally, the future development of citrate crystals is anticipated, and it is suggested that the combination of basic research and application research should be strengthened to explore the new application field of citrate crystals, and the automation and intelligence of the crystal preparation process should be realized as far as possible.

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Section: Main Methods For Citrate Crystallizationmentioning

confidence: 99%

Research Progress in the Industrial Crystallization of Citrate—A Review

Qin

Yan

et al. 2023

Crystals

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“…Three-phase crystallization (TPC), also known as stripping crystallization, was initially introduced by Shiau and his co-workers to separate mixed xylenes with close boiling temperatures. − Later, they applied TPC to separate chiral mixtures with the same boiling temperatures. − Basically, TPC combines melt crystallization and vaporization. Melt crystallization has long been adopted to obtain the desired crystalline solid from a liquid mixture via the solid–liquid transformation due to cooling at normal pressure. − TPC resembles melt crystallization operated at reduced pressure during the cooling process, leading to the formation of a crystalline product along with a vapor mixture from the liquid mixture via a series of three-phase transformations. If nearly all the liquid mixture is removed at the end of TPC, the final product only consists of the desired crystalline solid while the produced vapor can be collected and recycled.…”

Section: Introductionmentioning

confidence: 99%

Purification of p-Cresol, o-Cresol, m-Cresol, and 2,6-Xylenol from the Quaternary Mixture by Three-Phase Crystallization

Shiau

2023

Ind. Eng. Chem. Res.

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Three-phase crystallization (TPC) was applied in this work to purify the major component from quaternary liquid mixtures consisting of p-cresol, o-cresol, m-cresol, and 2,6-xylenol. As TPC is operated in a series of three-phase transformations by decreasing temperature and reducing pressure, TPC combines melt crystallization and vaporization to produce the major component crystalline product along with the vapor mixture from the liquid mixture. A model based on the van't Hoff equation and Raoult's law coupled with mass and energy balances was proposed to determine a series of three-phase transformation conditions, which were adopted to direct the batch TPC experiments. The experimental purity and recovery ratio of the final product for purification of pcresol, o-cresol, m-cresol, or 2,6-xylenol were compared with the calculated results predicted by the model. The order of difficulty for purification among p-cresol, o-cresol, m-cresol, and 2,6-xylenol was examined.

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“…Melt crystallization is an important separation process for the purification of organic compounds [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27] and enantiomeric mixtures [28,29]. The unique feature of melt crystallization is that no solvent is required; however, the subsequent separation of formed crystals from melt is often a challenging task for downstream processing.…”

Section: Introductionmentioning

confidence: 99%

The Influence of the Solid Solution Formation on Purification of L-Menthol from the Enantiomer Mixture by Three-Phase Crystallization

Hsu,

Yang,

et al. 2023

IJMS

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Three-phase crystallization (TPC) was introduced in this study to purify L-menthol from menthol enantiomer mixtures in consideration of the formation of solid solutions. TPC is a new separation technology, which combines melt crystallization and vaporization to result in the desired crystalline product from a liquid mixture along with the unwanted components vaporized via the three-phase transformation by reducing temperature and pressure. The three-phase transformation conditions for the liquid menthol enantiomer mixtures were determined based on the thermodynamic calculations to direct the TPC experiments. A new model was proposed based on the mass and energy balances in consideration of the formation of the solid solutions to predict the yield and purity of the final L-menthol product during TPC. The yield and purity obtained from the TPC experiments were compared with those predicted by the model.

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Recent progress in melt crystallization

Cited by 14 publications

References 42 publications

Research Progress in the Industrial Crystallization of Citrate—A Review

Research Progress in the Industrial Crystallization of Citrate—A Review

Purification of p-Cresol, o-Cresol, m-Cresol, and 2,6-Xylenol from the Quaternary Mixture by Three-Phase Crystallization

The Influence of the Solid Solution Formation on Purification of L-Menthol from the Enantiomer Mixture by Three-Phase Crystallization

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