A spiral axial-flow blade pump (SABP), as the core piece of equipment in the oil and natural gas closed-gathering and transportation process, can not only transport gas–liquid mixtures with a high gas content, but can also transport gas–liquid–solid mixtures containing small amounts of sand. However, due to the complexity of the distribution of transport media groups and the uncertainty of internal flow processes, large vortices often appear in the passage of the pumps, and the existence of vortices can easily induce the occurrence of pump cavitations. In the present work, a self-developed SABP was taken as the research object, and the cavitation performance of the SABP was numerically calculated. The pressure load variation under different tip clearances and different cavitation stages was analyzed, and the characteristics of the axial and radial forces were also analyzed in detail.